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• W2013313809 abstract "Objective To evaluate the role of topical interferon alfa-2b (IFNα2b) in the treatment of conjunctival and corneal intraepithelial neoplasia (CIN). Design Noncomparative case series. Participants Five patients with histologically proven CIN or recurrences of proven CIN were studied prospectively. Intervention After histologic confirmation, patients were given topical recombinant IFNα2b (INTRON A, Schering Plough, Kenilworth, NJ) 1 million IU/ml four times a day. Patients were continued on interferon until complete resolution of the tumor had occurred. Main outcome measures Patients were followed clinically and photographically for evidence of tumor resolution. Results All patients had complete resolution of the CIN lesion on IFNα2b. The mean time to clinical resolution was 11.6 weeks (range, 4–22 weeks). The mean follow-up was 17.6 months (range, 7–28 months). One patient had a clinical recurrence of his corneal CIN 1 year after tumor resolution. This patient was retreated, resulting in clinical resolution within 6 weeks, and has been tumor free for 8 months of follow-up." @default.
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• W2013313809 date "2001-06-01" @default.
• W2013313809 modified "2023-09-23" @default.
• W2013313809 title "Treatment of conjunctival and corneal intraepithelial neoplasia with topical interferon α-2b11The authors have no financial interest related to the article." @default.
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• W2013313809 doi "https://doi.org/10.1016/s0161-6420(01)00577-2" @default.
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