Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013314169> ?p ?o ?g. }
- W2013314169 abstract "The basal ganglia are thought to play a crucial role in reinforcement learning. Central to the learning mechanism are dopamine (DA) D1 and D2 receptors located in the cortico-striatal synapses. However, it is still unclear how this DA-mediated synaptic plasticity is deployed and coordinated during reward-contingent behavioral changes. Here we propose a computational model of reinforcement learning that uses different thresholds of D1- and D2-mediated synaptic plasticity which are antagonized by DA-independent synaptic plasticity. A phasic increase in DA release caused by a larger-than-expected reward induces long-term potentiation (LTP) in the direct pathway, whereas a phasic decrease in DA release caused by a smaller-than-expected reward induces a cessation of long-term depression, leading to LTP in the indirect pathway. This learning mechanism can explain the robust behavioral adaptation observed in a location-reward-value-association task where the animal makes shorter latency saccades to reward locations. The changes in saccade latency become quicker as the monkey becomes more experienced. This behavior can be explained by a switching mechanism which activates the cortico-striatal circuit selectively. Our model also shows how D1- or D2-receptor blocking experiments affect selectively either reward or no-reward trials. The proposed mechanisms also explain the behavioral changes in Parkinson's disease." @default.
- W2013314169 created "2016-06-24" @default.
- W2013314169 creator A5009985808 @default.
- W2013314169 creator A5072158096 @default.
- W2013314169 date "2011-01-01" @default.
- W2013314169 modified "2023-10-17" @default.
- W2013314169 title "Dopamine-Mediated Learning and Switching in Cortico-Striatal Circuit Explain Behavioral Changes in Reinforcement Learning" @default.
- W2013314169 cites W1605177041 @default.
- W2013314169 cites W1652173018 @default.
- W2013314169 cites W1748759529 @default.
- W2013314169 cites W1753238710 @default.
- W2013314169 cites W1786747796 @default.
- W2013314169 cites W1882131888 @default.
- W2013314169 cites W1882858722 @default.
- W2013314169 cites W1897438103 @default.
- W2013314169 cites W1966443363 @default.
- W2013314169 cites W1971797700 @default.
- W2013314169 cites W1971999279 @default.
- W2013314169 cites W1983297775 @default.
- W2013314169 cites W1983885921 @default.
- W2013314169 cites W1993109240 @default.
- W2013314169 cites W1996695526 @default.
- W2013314169 cites W2000702984 @default.
- W2013314169 cites W2003314029 @default.
- W2013314169 cites W2004011965 @default.
- W2013314169 cites W2009299837 @default.
- W2013314169 cites W2010073791 @default.
- W2013314169 cites W2013425429 @default.
- W2013314169 cites W2019078397 @default.
- W2013314169 cites W2019293912 @default.
- W2013314169 cites W2023365048 @default.
- W2013314169 cites W2025542749 @default.
- W2013314169 cites W2029725565 @default.
- W2013314169 cites W2033513858 @default.
- W2013314169 cites W2034128529 @default.
- W2013314169 cites W2037197807 @default.
- W2013314169 cites W2045629032 @default.
- W2013314169 cites W2045696805 @default.
- W2013314169 cites W2046713808 @default.
- W2013314169 cites W2047834876 @default.
- W2013314169 cites W2049356130 @default.
- W2013314169 cites W2049770398 @default.
- W2013314169 cites W2054649557 @default.
- W2013314169 cites W2055523610 @default.
- W2013314169 cites W2056331122 @default.
- W2013314169 cites W2058077554 @default.
- W2013314169 cites W2061863046 @default.
- W2013314169 cites W2065243100 @default.
- W2013314169 cites W2069618777 @default.
- W2013314169 cites W2076256116 @default.
- W2013314169 cites W2090763917 @default.
- W2013314169 cites W2092462980 @default.
- W2013314169 cites W2095051696 @default.
- W2013314169 cites W2095927624 @default.
- W2013314169 cites W2098526280 @default.
- W2013314169 cites W2100584953 @default.
- W2013314169 cites W2101392799 @default.
- W2013314169 cites W2105294045 @default.
- W2013314169 cites W2107425470 @default.
- W2013314169 cites W2109152498 @default.
- W2013314169 cites W2117726420 @default.
- W2013314169 cites W2118596861 @default.
- W2013314169 cites W2120677479 @default.
- W2013314169 cites W2123278801 @default.
- W2013314169 cites W2124953223 @default.
- W2013314169 cites W2127894602 @default.
- W2013314169 cites W2135090757 @default.
- W2013314169 cites W2146545384 @default.
- W2013314169 cites W2147801619 @default.
- W2013314169 cites W2150035284 @default.
- W2013314169 cites W2151316609 @default.
- W2013314169 cites W2154145851 @default.
- W2013314169 cites W2161438629 @default.
- W2013314169 cites W2162635653 @default.
- W2013314169 cites W2163647009 @default.
- W2013314169 cites W2164509516 @default.
- W2013314169 cites W2166495936 @default.
- W2013314169 cites W2167021628 @default.
- W2013314169 cites W2170171432 @default.
- W2013314169 cites W2261584825 @default.
- W2013314169 cites W2398662924 @default.
- W2013314169 doi "https://doi.org/10.3389/fnbeh.2011.00015" @default.
- W2013314169 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3065164" @default.
- W2013314169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21472026" @default.
- W2013314169 hasPublicationYear "2011" @default.
- W2013314169 type Work @default.
- W2013314169 sameAs 2013314169 @default.
- W2013314169 citedByCount "50" @default.
- W2013314169 countsByYear W20133141692012 @default.
- W2013314169 countsByYear W20133141692013 @default.
- W2013314169 countsByYear W20133141692014 @default.
- W2013314169 countsByYear W20133141692015 @default.
- W2013314169 countsByYear W20133141692016 @default.
- W2013314169 countsByYear W20133141692017 @default.
- W2013314169 countsByYear W20133141692018 @default.
- W2013314169 countsByYear W20133141692019 @default.
- W2013314169 countsByYear W20133141692020 @default.
- W2013314169 countsByYear W20133141692022 @default.
- W2013314169 countsByYear W20133141692023 @default.
- W2013314169 crossrefType "journal-article" @default.