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• W2013315852 abstract "Purpose This phase II study, evaluated the activity and cardiotoxicity of first-line epirubicin plus low-dose trastuzumab (LD-T) in patients with HER2 positive MBC. Methods Patients received epirubicin 90 mg/sqm every 3 weeks plus weekly LD-T (2 mg/kg loading dose, then 1 mg/kg). After 6/8 cycles of epirubicin, single agent trastuzumab was continued. Cardiotoxicity was defined as signs or symptoms of congestive heart failure (CHF), or ≥15% decline in LVEF without symptoms, or <15% LVEF decline to less than 50%, without symptoms. Results Forty-five patients were enrolled. Twenty-three received prior adjuvant anthracyclines. Overall response rate was 61.4%. The median time to progression was 7.4 months and the median survival was 32.8 months. Two (4.5%) patients developed CHF. Conclusions Epirubicin plus LD-T is an active regimen, however, the relatively high rate of cardiotoxicity together with the availability of less cardiotoxic and active trastuzumab-containing combinations precludes further evaluation of this regimen." @default.
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• W2013315852 date "2008-09-13" @default.
• W2013315852 modified "2023-10-10" @default.
• W2013315852 title "Epirubicin plus low-dose trastuzumab in HER2 positive metastatic breast cancer" @default.
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• W2013315852 doi "https://doi.org/10.1007/s10549-008-0048-8" @default.
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