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• W2013330474 endingPage "328" @default.
• W2013330474 startingPage "319" @default.
• W2013330474 abstract "The development of highly selective agonists for the two major subforms of the estrogen receptor (ERalpha and ERbeta) has produced new experimental methodologies for delineating the distinct functional role each plays in neurobehavioral biology. It has also been suggested that these compounds might have the potential to treat estrogen influenced behavioral disorders, such as anxiety and depression. Prior work has established that the ERbeta agonist, diarylpropionitrile (DPN) is anxiolytic in gonadectomized animals of both sexes, but whether or not this effect persists in gonadally intact individuals is unknown. Isoflavone phytoestrogens, also potent but less selective ERbeta agonists, have also been shown to influence anxiety in multiple species and are becoming more readily available to humans as health supplements. Here we determined the effects of 0.5, 1 or 2 mg/kg DPN, 1 mg/kg of the ERalpha agonist propyl-pyrazole-triol (PPT), 3 or 20 mg/kg of the isoflavone equol (EQ) and 3 or 20 mg/kg of the isoflavone polyphenol resveratrol (RES) on anxiety behavior in the gonadally intact male rat using the light/dark box and the elevated plus maze. We first determined that DPN can be successfully administered either orally or by subcutaneous injection, although plasma DPN levels are significantly lower if given orally. Once injected, plasma levels peak rapidly and then decline to baseline levels within 3 h of administration. For the behavioral studies, all compounds were injected and the animals were tested within 3 h of treatment. None of the compounds, at any of the doses, significantly altered anxiety-related behavior. Plasma testosterone levels were also not significantly altered suggesting that these compounds do not interfere with endogenous androgen levels. The results suggest that the efficacy of ERbeta agonists may depend on gonadal status. Therefore the therapeutic potential of ERbeta selective agonists to treat mood disorders may be limited." @default.
• W2013330474 created "2016-06-24" @default.
• W2013330474 creator A5021221028 @default.
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• W2013330474 creator A5056745479 @default.
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• W2013330474 creator A5074483490 @default.
• W2013330474 date "2009-02-01" @default.
• W2013330474 modified "2023-09-26" @default.
• W2013330474 title "Systemic administration of diarylpropionitrile (DPN) or phytoestrogens does not affect anxiety-related behaviors in gonadally intact male rats" @default.
• W2013330474 cites W1563446471 @default.
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• W2013330474 cites W1682534013 @default.
• W2013330474 cites W1901011363 @default.
• W2013330474 cites W1964244728 @default.
• W2013330474 cites W1973772110 @default.
• W2013330474 cites W1976392695 @default.
• W2013330474 cites W1979898922 @default.
• W2013330474 cites W1983151735 @default.
• W2013330474 cites W1985705387 @default.
• W2013330474 cites W1987321973 @default.
• W2013330474 cites W1990728215 @default.
• W2013330474 cites W1993872004 @default.
• W2013330474 cites W1996369704 @default.
• W2013330474 cites W1999658072 @default.
• W2013330474 cites W1999993860 @default.
• W2013330474 cites W2000557258 @default.
• W2013330474 cites W2001448855 @default.
• W2013330474 cites W2003316529 @default.
• W2013330474 cites W2011735277 @default.
• W2013330474 cites W2014011509 @default.
• W2013330474 cites W2019455802 @default.
• W2013330474 cites W2023314887 @default.
• W2013330474 cites W2023433109 @default.
• W2013330474 cites W2023471562 @default.
• W2013330474 cites W2026836636 @default.
• W2013330474 cites W2032260926 @default.
• W2013330474 cites W2032946628 @default.
• W2013330474 cites W2034144737 @default.
• W2013330474 cites W2038992545 @default.
• W2013330474 cites W2039725741 @default.
• W2013330474 cites W2040801339 @default.
• W2013330474 cites W2041561931 @default.
• W2013330474 cites W2042179361 @default.
• W2013330474 cites W2044170250 @default.
• W2013330474 cites W2051185023 @default.
• W2013330474 cites W2053817786 @default.
• W2013330474 cites W2054530383 @default.
• W2013330474 cites W2065785294 @default.
• W2013330474 cites W2068757410 @default.
• W2013330474 cites W2072276309 @default.
• W2013330474 cites W2073353512 @default.
• W2013330474 cites W2077221091 @default.
• W2013330474 cites W2080190440 @default.
• W2013330474 cites W2081023207 @default.
• W2013330474 cites W2088381487 @default.
• W2013330474 cites W2088708383 @default.
• W2013330474 cites W2092411075 @default.
• W2013330474 cites W2092953670 @default.
• W2013330474 cites W2102889645 @default.
• W2013330474 cites W2103935685 @default.
• W2013330474 cites W2111092938 @default.
• W2013330474 cites W2112118785 @default.
• W2013330474 cites W2114379216 @default.
• W2013330474 cites W2116480637 @default.
• W2013330474 cites W2118089000 @default.
• W2013330474 cites W2121563365 @default.
• W2013330474 cites W2125121177 @default.
• W2013330474 cites W2127394341 @default.
• W2013330474 cites W2130113892 @default.
• W2013330474 cites W2136564303 @default.
• W2013330474 cites W2138107646 @default.
• W2013330474 cites W2152777736 @default.
• W2013330474 cites W2155225555 @default.
• W2013330474 cites W2162934389 @default.
• W2013330474 cites W4240866307 @default.
• W2013330474 cites W4251409858 @default.
• W2013330474 cites W4254929185 @default.
• W2013330474 doi "https://doi.org/10.1016/j.yhbeh.2008.11.004" @default.
• W2013330474 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2654784" @default.
• W2013330474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19071129" @default.
• W2013330474 hasPublicationYear "2009" @default.
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