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• W2013330992 abstract "Hepatic monodeiodination of thyroxine (T4), reverse triiodothyronine (rT3), and triiodothyronine (T3) are enzymic reactions that depend on tissue concentrations of sulfhydryl (SH) groups. Fasting in the rat is associated with low serum concentration of thyroid hormones (T4 and T3), a low rate of hepatic 5′-monodeiodination of T4, and low tissue concentrations of nonprotein SH (NP-SH) groups. This study describes the relationship between these various abnormalities and the effect of fasting on conversion of rT3 and T3 to 3,3′-diiodothyronine (3,3′-T2). Male Sprague-Dawley rats weighing 150–220 g were sacrificed after fasting for 0, 1, 2, and 4 days and iodothyronine monodeiodinations and total SH (T-SH) and NP-SH concentrations were quantified in liver homogenates. Hepatic T-SH concentration did not change appreciably during fasting. However, NP-SH levels decreased considerably at 1 day and then gradually recovered to or towards normal by 4 days of fasting. Hepatic NP-SH concentration in a representative experiment was 6.2 ± 0.20 μM/g in controls and 4.1 ± 0.49, 5.2 ± 0.36, and 6.9 ± 1.2 μM/g (mean ± SE) at 1, 2, and 4 days of fasting, respectively. On the other hand, T4-T3 converting activity (ng T3 produced/μg T4/geq tissue/hr) decreased progressively from 219 ± 15 in controls to 205 ± 18, 166 ± 6.7, (p < 0.005) and 149 ± 10 (p < 0.005) at 1, 2, and 4 days of fasting, respectively. Addition of dithiothreitol (DTT) to liver homogenates of 2-day (412 ± 15) and 4-day (397 ± 42) fasted rats did not render T3 production from T4 comparable to that in control animals (613 ± 76). When rats were treated with T4 (), changes in liver NP-SH still occurred as mentioned. However, hepatic T4-T3 conversion was reduced (193 ± 11 versus 352 ± 29, p < 0.005) only at 2 days when NP-SH was low, and it increased normally after addition of DTT (691 ± 26 versus 823 ± 74, NS). It was normal in absence (357 ± 67) and in presence (872 ± 68) of DTT at 4 days of fasting when NP-SH was normal. Monodeiodination of T3 to 3,3′-T2 was normal in fasting, whereas that of rT3 was low but normalized with DTT. The various data suggest that (1) low tissue NP-SH levels are important in causing the reduction in hepatic T4 5′-monodeiodination only early in fasting (subsequently, hypothyroidism is the key factor); and (2) inner ring monodeiodination of T3 is normal in fasting." @default.
• W2013330992 created "2016-06-24" @default.
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• W2013330992 date "1980-02-01" @default.
• W2013330992 modified "2023-09-27" @default.
• W2013330992 title "Alterations in monodeiodination of iodothyronines in the fasting rat: Effects of reduced nonprotein sulfhydryl groups and hypothyroidism" @default.
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• W2013330992 doi "https://doi.org/10.1016/0026-0495(80)90141-9" @default.
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