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- W2013333512 abstract "Jembrana disease virus (JDV) is an unusual bovine lentivirus which causes a non-follicular proliferation of lymphocytes, a transient immunosuppression and a delayed humoral response in infected Bali cattle in Indonesia. A double-immunofluorescent labeling method was developed to identify the subset of mononuclear cells in which the viral capsid protein could be detected. Viral antigen was present in pleomorphic centroblast-like cells which were identified as IgG-containing cells, including plasma cells, in lymphoid tissues. There was no evidence of infection of CD3+ T-cells or MAC387+ monocytes in tissues but large vacuolated cells with a macrophage-like morphology in the lung were found to contain viral antigen although they could not be shown conclusively to be infected. The tropism of JDV for mature IgG-containing cells may be relevant to understanding the pathogenesis of Jembrana disease, the delayed antibody responses and the genetic composition of this atypical lentivirus." @default.
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- W2013333512 date "2009-10-01" @default.
- W2013333512 modified "2023-09-25" @default.
- W2013333512 title "In vivo infection of IgG-containing cells by Jembrana disease virus during acute infection" @default.
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- W2013333512 doi "https://doi.org/10.1016/j.virol.2009.07.027" @default.
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