FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013336265> ?p ?o ?g. }

• W2013336265 endingPage "5824" @default.
• W2013336265 startingPage "5819" @default.
• W2013336265 abstract "ABSTRACT An oligonucleotide biochip that specifically detects point mutations in the gyrA and parC genes of Neisseria gonorrhoeae was designed and subsequently evaluated with 87 untreated clinical specimens. The susceptibilities of the N. gonorrhoeae strains were tested to determine the prevalence of ciprofloxacin-resistant strains in Anhui Province, People's Republic of China. Conventional DNA sequencing was also performed to identify mutations in gyrA and parC and to confirm the biochip data. The study demonstrates that all of the point mutations in the gyrA and parC genes of N. gonorrhoeae were easily discriminated by use of the oligonucleotide biochip. Fifteen different alteration patterns involved in the formation of ciprofloxacin resistance were identified by the biochip assay. Double mutations in both Ser91 and Asp95 of the GyrA protein were seen in all nonsensitive isolates. Double mutations in Ser91 and Asp95 of GyrA plus mutation of Glu91 or Ser87 of the ParC protein lead to significant high-level resistance to ciprofloxacin in N. gonorrhoeae isolates. The results obtained by use of the oligonucleotide biochip were identical to those obtained by use of DNA sequencing. In conclusion, the oligonucleotide biochip technology has potential utility for the rapid and reliable identification of point mutations in the drug resistance genes of N. gonorrhoeae." @default.
• W2013336265 created "2016-06-24" @default.
• W2013336265 creator A5000432967 @default.
• W2013336265 creator A5001078737 @default.
• W2013336265 creator A5001084384 @default.
• W2013336265 creator A5006440771 @default.
• W2013336265 creator A5012436877 @default.
• W2013336265 creator A5014475350 @default.
• W2013336265 creator A5031857309 @default.
• W2013336265 creator A5049703242 @default.
• W2013336265 creator A5053613555 @default.
• W2013336265 creator A5087981683 @default.
• W2013336265 date "2004-12-01" @default.
• W2013336265 modified "2023-10-16" @default.
• W2013336265 title "Detection of gyrA and parC Mutations Associated with Ciprofloxacin Resistance in Neisseria gonorrhoeae by Use of Oligonucleotide Biochip Technology" @default.
• W2013336265 cites W1659510881 @default.
• W2013336265 cites W1793129498 @default.
• W2013336265 cites W1971635124 @default.
• W2013336265 cites W1975188059 @default.
• W2013336265 cites W1978861792 @default.
• W2013336265 cites W1993163345 @default.
• W2013336265 cites W1998640667 @default.
• W2013336265 cites W2000334423 @default.
• W2013336265 cites W2010083350 @default.
• W2013336265 cites W2015341941 @default.
• W2013336265 cites W2030958510 @default.
• W2013336265 cites W2046995141 @default.
• W2013336265 cites W2057043036 @default.
• W2013336265 cites W2058937442 @default.
• W2013336265 cites W2063733823 @default.
• W2013336265 cites W2073070220 @default.
• W2013336265 cites W2082504556 @default.
• W2013336265 cites W2094807555 @default.
• W2013336265 cites W2096027924 @default.
• W2013336265 cites W2096767316 @default.
• W2013336265 cites W2097583000 @default.
• W2013336265 cites W2122273366 @default.
• W2013336265 cites W2128195721 @default.
• W2013336265 cites W2162790021 @default.
• W2013336265 cites W2168532852 @default.
• W2013336265 cites W4298249888 @default.
• W2013336265 cites W2065855848 @default.
• W2013336265 doi "https://doi.org/10.1128/jcm.42.12.5819-5824.2004" @default.
• W2013336265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/535257" @default.
• W2013336265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15583317" @default.
• W2013336265 hasPublicationYear "2004" @default.
• W2013336265 type Work @default.
• W2013336265 sameAs 2013336265 @default.
• W2013336265 citedByCount "19" @default.
• W2013336265 countsByYear W20133362652012 @default.
• W2013336265 countsByYear W20133362652013 @default.
• W2013336265 countsByYear W20133362652014 @default.
• W2013336265 countsByYear W20133362652015 @default.
• W2013336265 countsByYear W20133362652016 @default.
• W2013336265 countsByYear W20133362652021 @default.
• W2013336265 crossrefType "journal-article" @default.
• W2013336265 hasAuthorship W2013336265A5000432967 @default.
• W2013336265 hasAuthorship W2013336265A5001078737 @default.
• W2013336265 hasAuthorship W2013336265A5001084384 @default.
• W2013336265 hasAuthorship W2013336265A5006440771 @default.
• W2013336265 hasAuthorship W2013336265A5012436877 @default.
• W2013336265 hasAuthorship W2013336265A5014475350 @default.
• W2013336265 hasAuthorship W2013336265A5031857309 @default.
• W2013336265 hasAuthorship W2013336265A5049703242 @default.
• W2013336265 hasAuthorship W2013336265A5053613555 @default.
• W2013336265 hasAuthorship W2013336265A5087981683 @default.
• W2013336265 hasBestOaLocation W20133362651 @default.
• W2013336265 hasConcept C104317684 @default.
• W2013336265 hasConcept C129312508 @default.
• W2013336265 hasConcept C153911025 @default.
• W2013336265 hasConcept C159047783 @default.
• W2013336265 hasConcept C176944494 @default.
• W2013336265 hasConcept C2778512257 @default.
• W2013336265 hasConcept C2779166590 @default.
• W2013336265 hasConcept C501593827 @default.
• W2013336265 hasConcept C501734568 @default.
• W2013336265 hasConcept C54355233 @default.
• W2013336265 hasConcept C86803240 @default.
• W2013336265 hasConcept C87892846 @default.
• W2013336265 hasConcept C89423630 @default.
• W2013336265 hasConceptScore W2013336265C104317684 @default.
• W2013336265 hasConceptScore W2013336265C129312508 @default.
• W2013336265 hasConceptScore W2013336265C153911025 @default.
• W2013336265 hasConceptScore W2013336265C159047783 @default.
• W2013336265 hasConceptScore W2013336265C176944494 @default.
• W2013336265 hasConceptScore W2013336265C2778512257 @default.
• W2013336265 hasConceptScore W2013336265C2779166590 @default.
• W2013336265 hasConceptScore W2013336265C501593827 @default.
• W2013336265 hasConceptScore W2013336265C501734568 @default.
• W2013336265 hasConceptScore W2013336265C54355233 @default.
• W2013336265 hasConceptScore W2013336265C86803240 @default.
• W2013336265 hasConceptScore W2013336265C87892846 @default.
• W2013336265 hasConceptScore W2013336265C89423630 @default.
• W2013336265 hasIssue "12" @default.
• W2013336265 hasLocation W20133362651 @default.
• W2013336265 hasLocation W20133362652 @default.
• W2013336265 hasLocation W20133362653 @default.
• W2013336265 hasLocation W20133362654 @default.

• next