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- W2013341391 abstract "The retinal pigment epithelium (RPE) is indispensable for vertebrate eye development and vision. In the classical model of optic vesicle patterning, the surface ectoderm produces fibroblast growth factors (FGFs) that specify the neural retina (NR) distally, whereas TGFβ family members released from the proximal mesenchyme are involved in RPE specification. However, we previously proposed that bone morphogenetic proteins (BMPs) released from the surface ectoderm are essential for RPE specification in chick. We now show that the BMP- and Wnt-expressing surface ectoderm is required for RPE specification. We reveal that Wnt signalling from the overlying surface ectoderm is involved in restricting BMP-mediated RPE specification to the dorsal optic vesicle. Wnt2b is expressed in the dorsal surface ectoderm and subsequently in dorsal optic vesicle cells. Activation of Wnt signalling by implanting Wnt3a-soaked beads or inhibiting GSK3β at optic vesicle stages inhibits NR development and converts the entire optic vesicle into RPE. Surface ectoderm removal at early optic vesicle stages or inhibition of Wnt, but not Wnt/β-catenin, signalling prevents pigmentation and downregulates the RPE regulatory gene Mitf. Activation of BMP or Wnt signalling can replace the surface ectoderm to rescue MITF expression and optic cup formation. We provide evidence that BMPs and Wnts cooperate via a GSK3β-dependent but β-catenin-independent pathway at the level of pSmad to ensure RPE specification in dorsal optic vesicle cells. We propose a new dorsoventral model of optic vesicle patterning, whereby initially surface ectoderm-derived Wnt signalling directs dorsal optic vesicle cells to develop into RPE through a stabilising effect of BMP signalling." @default.
- W2013341391 created "2016-06-24" @default.
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- W2013341391 date "2013-12-15" @default.
- W2013341391 modified "2023-09-30" @default.
- W2013341391 title "RPE specification in the chick is mediated by surface ectoderm-derived BMP and Wnt signalling" @default.
- W2013341391 cites W1509287381 @default.
- W2013341391 cites W158914514 @default.
- W2013341391 cites W1599436863 @default.
- W2013341391 cites W1668580308 @default.
- W2013341391 cites W1844859101 @default.
- W2013341391 cites W1854873323 @default.
- W2013341391 cites W1969740535 @default.
- W2013341391 cites W1971163936 @default.
- W2013341391 cites W1973963032 @default.
- W2013341391 cites W1974660048 @default.
- W2013341391 cites W1977495197 @default.
- W2013341391 cites W1978140823 @default.
- W2013341391 cites W1982579673 @default.
- W2013341391 cites W1985157487 @default.
- W2013341391 cites W1987716089 @default.
- W2013341391 cites W1989526275 @default.
- W2013341391 cites W1991626630 @default.
- W2013341391 cites W1992127683 @default.
- W2013341391 cites W1995501385 @default.
- W2013341391 cites W1999966222 @default.
- W2013341391 cites W2001910980 @default.
- W2013341391 cites W2005607646 @default.
- W2013341391 cites W2010290950 @default.
- W2013341391 cites W2014684686 @default.
- W2013341391 cites W2015029839 @default.
- W2013341391 cites W2019668010 @default.
- W2013341391 cites W2022962960 @default.
- W2013341391 cites W2031112866 @default.
- W2013341391 cites W2034446023 @default.
- W2013341391 cites W2035797804 @default.
- W2013341391 cites W2037132744 @default.
- W2013341391 cites W2037723919 @default.
- W2013341391 cites W2040953801 @default.
- W2013341391 cites W2042013946 @default.
- W2013341391 cites W2046373631 @default.
- W2013341391 cites W2046770273 @default.
- W2013341391 cites W2047098849 @default.
- W2013341391 cites W2048511036 @default.
- W2013341391 cites W2050991107 @default.
- W2013341391 cites W2052478761 @default.
- W2013341391 cites W2053928527 @default.
- W2013341391 cites W2062845601 @default.
- W2013341391 cites W2069409989 @default.
- W2013341391 cites W2073947789 @default.
- W2013341391 cites W2074314696 @default.
- W2013341391 cites W2077252586 @default.
- W2013341391 cites W2079148785 @default.
- W2013341391 cites W2079819294 @default.
- W2013341391 cites W2083698768 @default.
- W2013341391 cites W2083705372 @default.
- W2013341391 cites W2087526418 @default.
- W2013341391 cites W2087623075 @default.
- W2013341391 cites W2090210604 @default.
- W2013341391 cites W2090495050 @default.
- W2013341391 cites W2094099083 @default.
- W2013341391 cites W2097689792 @default.
- W2013341391 cites W2100006596 @default.
- W2013341391 cites W2104406613 @default.
- W2013341391 cites W2115438940 @default.
- W2013341391 cites W2120385245 @default.
- W2013341391 cites W2121104839 @default.
- W2013341391 cites W2124760311 @default.
- W2013341391 cites W2129584348 @default.
- W2013341391 cites W2133895525 @default.
- W2013341391 cites W2135767680 @default.
- W2013341391 cites W2140034535 @default.
- W2013341391 cites W2142364124 @default.
- W2013341391 cites W2143210568 @default.
- W2013341391 cites W2143279020 @default.
- W2013341391 cites W2144300395 @default.
- W2013341391 cites W2145890888 @default.
- W2013341391 cites W2147373137 @default.
- W2013341391 cites W2151928801 @default.
- W2013341391 cites W2154883208 @default.
- W2013341391 cites W2157766742 @default.
- W2013341391 cites W2158021558 @default.
- W2013341391 cites W2165250124 @default.
- W2013341391 cites W2166355740 @default.
- W2013341391 cites W2166792046 @default.
- W2013341391 cites W2170354499 @default.
- W2013341391 cites W2184743415 @default.
- W2013341391 doi "https://doi.org/10.1242/dev.096990" @default.
- W2013341391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24227655" @default.
- W2013341391 hasPublicationYear "2013" @default.
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