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- W2013341625 abstract "F-18-labeled porphyrins, the potential tracing and detecting agents for tumor have been synthesized and characterized by two convenient routes: one is a mixed aldehyde condensation, which involves acid-catalyzed condensation of pyrrole, m-anisaldehyde and 4-[18F]fluorobenzaldehyde. The other is the acid-catalyzed condensation of tetrapyrrane with 4-[18F]fluorobenzaldehyde. The synthetic methodologies including solvents, reaction concentrations and catalysts are optimized for radiolabeled porphyrins. The methods also provide the desired product in reasonable radiochemical yield (20–26%) compared with those of cold chemical synthesis (1–3%) and with high radiochemical purity (>95%). The methods described here would be effective and convenient ways to produce radiolabeled porphyrin. Copyright © 2005 John Wiley & Sons, Ltd." @default.
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- W2013341625 date "2005-01-01" @default.
- W2013341625 modified "2023-09-25" @default.
- W2013341625 title "Efficient methods for the synthesis of 5-(4-[18F]fluorophenyl)-10,15,20-tris(3-methoxyphenyl)porphyrin as a potential imaging agent for tumor" @default.
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- W2013341625 doi "https://doi.org/10.1002/jlcr.992" @default.
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