Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013346724> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2013346724 endingPage "64S" @default.
- W2013346724 startingPage "63S" @default.
- W2013346724 abstract "Endothelin (ET)-1 is a potent vasoconstrictor elicited from endothelial cells in response to a variety of stimuli and an important mediator for a variety of vascular diseases including pulmonary hypertension. In this paper, we describe the molecular regulation of the ET-1 gene in response to a vasoactive mediator, thrombin, in human pulmonary endothelial cells. Thrombin induces preproET-1 mRNA through a transcriptionally dependent mechanism, with a peak induction after 1 h of exposure. Analysis of chromatin structure identified several DNase I-hypersensitive regions under both basal and thrombin-stimulated conditions that reside in the 5'-promoter region, indicating that the ET-1 promoter is a constitutive promoter. Deletion analysis was employed as a functional assay to identify regions of the ET-1 promoter that are important in transcriptional regulation. We found that sites between -141 and -378 bp are essential for basal activity and that those between -378 and -484 bp are essential for thrombin-stimulated activity. However, full expression under both conditions required an element(s) within -952 bp." @default.
- W2013346724 created "2016-06-24" @default.
- W2013346724 creator A5011158103 @default.
- W2013346724 creator A5053711712 @default.
- W2013346724 creator A5056981082 @default.
- W2013346724 date "1998-07-01" @default.
- W2013346724 modified "2023-09-26" @default.
- W2013346724 title "Thrombin Regulation of Endothelin-1 Gene in Isolated Human Pulmonary Endothelial Cells" @default.
- W2013346724 cites W1500713135 @default.
- W2013346724 cites W1607853670 @default.
- W2013346724 cites W2022982030 @default.
- W2013346724 cites W2067862793 @default.
- W2013346724 cites W2120381920 @default.
- W2013346724 cites W2331798828 @default.
- W2013346724 cites W4236390702 @default.
- W2013346724 doi "https://doi.org/10.1378/chest.114.1_supplement.63s" @default.
- W2013346724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9676632" @default.
- W2013346724 hasPublicationYear "1998" @default.
- W2013346724 type Work @default.
- W2013346724 sameAs 2013346724 @default.
- W2013346724 citedByCount "1" @default.
- W2013346724 countsByYear W20133467242013 @default.
- W2013346724 crossrefType "journal-article" @default.
- W2013346724 hasAuthorship W2013346724A5011158103 @default.
- W2013346724 hasAuthorship W2013346724A5053711712 @default.
- W2013346724 hasAuthorship W2013346724A5056981082 @default.
- W2013346724 hasConcept C104317684 @default.
- W2013346724 hasConcept C126322002 @default.
- W2013346724 hasConcept C144980905 @default.
- W2013346724 hasConcept C149601957 @default.
- W2013346724 hasConcept C170493617 @default.
- W2013346724 hasConcept C203014093 @default.
- W2013346724 hasConcept C2777292125 @default.
- W2013346724 hasConcept C2909649922 @default.
- W2013346724 hasConcept C3018972837 @default.
- W2013346724 hasConcept C54355233 @default.
- W2013346724 hasConcept C71924100 @default.
- W2013346724 hasConcept C86803240 @default.
- W2013346724 hasConcept C89560881 @default.
- W2013346724 hasConceptScore W2013346724C104317684 @default.
- W2013346724 hasConceptScore W2013346724C126322002 @default.
- W2013346724 hasConceptScore W2013346724C144980905 @default.
- W2013346724 hasConceptScore W2013346724C149601957 @default.
- W2013346724 hasConceptScore W2013346724C170493617 @default.
- W2013346724 hasConceptScore W2013346724C203014093 @default.
- W2013346724 hasConceptScore W2013346724C2777292125 @default.
- W2013346724 hasConceptScore W2013346724C2909649922 @default.
- W2013346724 hasConceptScore W2013346724C3018972837 @default.
- W2013346724 hasConceptScore W2013346724C54355233 @default.
- W2013346724 hasConceptScore W2013346724C71924100 @default.
- W2013346724 hasConceptScore W2013346724C86803240 @default.
- W2013346724 hasConceptScore W2013346724C89560881 @default.
- W2013346724 hasIssue "1" @default.
- W2013346724 hasLocation W20133467241 @default.
- W2013346724 hasLocation W20133467242 @default.
- W2013346724 hasOpenAccess W2013346724 @default.
- W2013346724 hasPrimaryLocation W20133467241 @default.
- W2013346724 hasRelatedWork W2009892925 @default.
- W2013346724 hasRelatedWork W2013346724 @default.
- W2013346724 hasRelatedWork W2022572247 @default.
- W2013346724 hasRelatedWork W2026138201 @default.
- W2013346724 hasRelatedWork W2030457325 @default.
- W2013346724 hasRelatedWork W2036532185 @default.
- W2013346724 hasRelatedWork W2053386973 @default.
- W2013346724 hasRelatedWork W2055609467 @default.
- W2013346724 hasRelatedWork W2355917248 @default.
- W2013346724 hasRelatedWork W2401811509 @default.
- W2013346724 hasVolume "114" @default.
- W2013346724 isParatext "false" @default.
- W2013346724 isRetracted "false" @default.
- W2013346724 magId "2013346724" @default.
- W2013346724 workType "article" @default.