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- W2013348596 abstract "The activation of a cyclic nucleotide-gated channel is the final step in sensory transduction in olfaction. Normally, this channel is opened by the intracellular cyclic nucleotide second messenger cAMP or cGMP. However, in single channel recordings we found that donors of nitric oxide, a putative intercellular messenger, could directly activate the native olfactory neuron channel. Its action was independent of the presence of the normal ligand and did not involve the cyclic nucleotide binding site, suggesting an alternate site on the molecule that is critical in channel gating. The biochemical pathway appears to utilize nitric oxide in one of its alternate redox states, the nitrosonium ion, transnitrosylating a free sulfhydryl group belonging to a cysteine residue tentatively identified as being in the region linking the S6 transmembrane domain to the ligand binding domain." @default.
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- W2013348596 date "1996-02-01" @default.
- W2013348596 modified "2023-10-18" @default.
- W2013348596 title "Direct Activation of the Olfactory Cyclic Nucleotide–Gated Channel through Modification of Sulfhydryl Groups by NO Compounds" @default.
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- W2013348596 doi "https://doi.org/10.1016/s0896-6273(00)80055-0" @default.
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