FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013355917> ?p ?o ?g. }

• W2013355917 endingPage "80" @default.
• W2013355917 startingPage "72" @default.
• W2013355917 abstract "Deregulated CMYC gene causes cell transformation and is often correlated with tumor progression and a worse clinical outcome of cancer patients. The transcription factor Myc functions by heterodimerizing with its partner, Max. As a strategy to inhibit Myc activity, we have synthesized three small peptides corresponding to segments of the leucine zipper (LZ) region of Max. The purpose of these peptides is to occupy the site of recognition between Myc and Max located in the LZ and inhibit-specific heterodimerization between these proteins. We have used the synthesized oligopeptides in two lung cancer cell lines with different levels of Myc expression. Results demonstrate that: (i) the three peptides resulted equally effective in competing the interaction between Myc and Max in vitro; (ii) they were efficiently internalized into the cells and significantly inhibited cell growth in the cells showing the highest Myc expression; (iii) one specific peptide, only nine aminoacids long, efficiently impaired the transcriptional activity of Myc in vivo, showing a more stable interaction with this protein. Our results are relevant to the development of novel anti-tumoral therapeutic strategies, directed to Myc-overexpressing tumors. J. Cell. Physiol. 210: 72–80, 2007. © 2006 Wiley-Liss, Inc." @default.
• W2013355917 created "2016-06-24" @default.
• W2013355917 creator A5022166666 @default.
• W2013355917 creator A5022461322 @default.
• W2013355917 creator A5029713570 @default.
• W2013355917 creator A5031477185 @default.
• W2013355917 creator A5052859661 @default.
• W2013355917 date "2006-01-01" @default.
• W2013355917 modified "2023-09-27" @default.
• W2013355917 title "Oligopeptides impairing the Myc-Max heterodimerization inhibit lung cancer cell proliferation by reducing Myc transcriptional activity" @default.
• W2013355917 cites W1547608553 @default.
• W2013355917 cites W1549051606 @default.
• W2013355917 cites W1816025869 @default.
• W2013355917 cites W1922521877 @default.
• W2013355917 cites W1966135653 @default.
• W2013355917 cites W1990264812 @default.
• W2013355917 cites W1996795280 @default.
• W2013355917 cites W1997813173 @default.
• W2013355917 cites W2004923643 @default.
• W2013355917 cites W2016683877 @default.
• W2013355917 cites W2018093071 @default.
• W2013355917 cites W2020365958 @default.
• W2013355917 cites W2030618323 @default.
• W2013355917 cites W2034269086 @default.
• W2013355917 cites W2042777921 @default.
• W2013355917 cites W2064772366 @default.
• W2013355917 cites W2065617142 @default.
• W2013355917 cites W2080443370 @default.
• W2013355917 cites W2082027741 @default.
• W2013355917 cites W2084203064 @default.
• W2013355917 cites W2085213714 @default.
• W2013355917 cites W2094619972 @default.
• W2013355917 cites W2096755059 @default.
• W2013355917 cites W2098924171 @default.
• W2013355917 cites W2115165466 @default.
• W2013355917 cites W2119626222 @default.
• W2013355917 cites W2135944212 @default.
• W2013355917 cites W2149357952 @default.
• W2013355917 cites W2151131756 @default.
• W2013355917 cites W2156543879 @default.
• W2013355917 cites W2158110021 @default.
• W2013355917 cites W2167150841 @default.
• W2013355917 cites W2339646853 @default.
• W2013355917 cites W4245676270 @default.
• W2013355917 cites W2043274718 @default.
• W2013355917 doi "https://doi.org/10.1002/jcp.20810" @default.
• W2013355917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16998799" @default.
• W2013355917 hasPublicationYear "2006" @default.
• W2013355917 type Work @default.
• W2013355917 sameAs 2013355917 @default.
• W2013355917 citedByCount "6" @default.
• W2013355917 countsByYear W20133559172016 @default.
• W2013355917 crossrefType "journal-article" @default.
• W2013355917 hasAuthorship W2013355917A5022166666 @default.
• W2013355917 hasAuthorship W2013355917A5022461322 @default.
• W2013355917 hasAuthorship W2013355917A5029713570 @default.
• W2013355917 hasAuthorship W2013355917A5031477185 @default.
• W2013355917 hasAuthorship W2013355917A5052859661 @default.
• W2013355917 hasBestOaLocation W20133559171 @default.
• W2013355917 hasConcept C104317684 @default.
• W2013355917 hasConcept C13935069 @default.
• W2013355917 hasConcept C1491633281 @default.
• W2013355917 hasConcept C153911025 @default.
• W2013355917 hasConcept C156860981 @default.
• W2013355917 hasConcept C202751555 @default.
• W2013355917 hasConcept C207001950 @default.
• W2013355917 hasConcept C2779281246 @default.
• W2013355917 hasConcept C2910353367 @default.
• W2013355917 hasConcept C502942594 @default.
• W2013355917 hasConcept C54355233 @default.
• W2013355917 hasConcept C55493867 @default.
• W2013355917 hasConcept C62112901 @default.
• W2013355917 hasConcept C81885089 @default.
• W2013355917 hasConcept C86339819 @default.
• W2013355917 hasConcept C86803240 @default.
• W2013355917 hasConceptScore W2013355917C104317684 @default.
• W2013355917 hasConceptScore W2013355917C13935069 @default.
• W2013355917 hasConceptScore W2013355917C1491633281 @default.
• W2013355917 hasConceptScore W2013355917C153911025 @default.
• W2013355917 hasConceptScore W2013355917C156860981 @default.
• W2013355917 hasConceptScore W2013355917C202751555 @default.
• W2013355917 hasConceptScore W2013355917C207001950 @default.
• W2013355917 hasConceptScore W2013355917C2779281246 @default.
• W2013355917 hasConceptScore W2013355917C2910353367 @default.
• W2013355917 hasConceptScore W2013355917C502942594 @default.
• W2013355917 hasConceptScore W2013355917C54355233 @default.
• W2013355917 hasConceptScore W2013355917C55493867 @default.
• W2013355917 hasConceptScore W2013355917C62112901 @default.
• W2013355917 hasConceptScore W2013355917C81885089 @default.
• W2013355917 hasConceptScore W2013355917C86339819 @default.
• W2013355917 hasConceptScore W2013355917C86803240 @default.
• W2013355917 hasIssue "1" @default.
• W2013355917 hasLocation W20133559171 @default.
• W2013355917 hasLocation W20133559172 @default.
• W2013355917 hasOpenAccess W2013355917 @default.
• W2013355917 hasPrimaryLocation W20133559171 @default.
• W2013355917 hasRelatedWork W1981071014 @default.
• W2013355917 hasRelatedWork W1995079250 @default.

• next