Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013359545> ?p ?o ?g. }
- W2013359545 endingPage "406" @default.
- W2013359545 startingPage "397" @default.
- W2013359545 abstract "Microglial activation worsens neuronal loss and contributes to progressive neurological diseases like Parkinson's disease (PD). This inflammatory progression is countered by dynorphin (Dyn), the endogenous ligand of the kappa-opioid receptor (KOR). We show that microglial β-arrestin mediates the ability of Dyn/KOR to limit endotoxin-elicited production of pro-inflammatory effectors and cytokines, subsequently protecting neurons from inflammation-induced neurotoxicity. Agonist-activated KOR enhances the interaction of β-arrestin2 with transforming growth factor-beta-activated kinase 1 (TAK1)-binding protein 1 (TAB1), disrupting TAK1-TAB1 mediated pro-inflammatory gene expression. We reveal a new physiological role for β-arrestin in neuroprotection via receptor internalization-triggered blockade of signal effectors of microglial inflammatory neurotoxicity. This result offers novel drug targets in the convergent KOR/β-arrestin2 and inflammatory pathways for treating microglial inflammatory neuropathologies like PD." @default.
- W2013359545 created "2016-06-24" @default.
- W2013359545 creator A5014354004 @default.
- W2013359545 creator A5034365665 @default.
- W2013359545 creator A5050453522 @default.
- W2013359545 creator A5061330941 @default.
- W2013359545 creator A5084800710 @default.
- W2013359545 date "2013-10-25" @default.
- W2013359545 modified "2023-10-18" @default.
- W2013359545 title "β-arrestin protects neurons by mediating endogenous opioid arrest of inflammatory microglia" @default.
- W2013359545 cites W1933410007 @default.
- W2013359545 cites W1962674088 @default.
- W2013359545 cites W1965572881 @default.
- W2013359545 cites W1974924674 @default.
- W2013359545 cites W1980020952 @default.
- W2013359545 cites W1980266334 @default.
- W2013359545 cites W1981408589 @default.
- W2013359545 cites W1987507313 @default.
- W2013359545 cites W1991805788 @default.
- W2013359545 cites W1994942139 @default.
- W2013359545 cites W2001176185 @default.
- W2013359545 cites W2001564857 @default.
- W2013359545 cites W2003757791 @default.
- W2013359545 cites W2004349171 @default.
- W2013359545 cites W2007606516 @default.
- W2013359545 cites W2010531200 @default.
- W2013359545 cites W2011041372 @default.
- W2013359545 cites W2017391589 @default.
- W2013359545 cites W2018631912 @default.
- W2013359545 cites W2027308361 @default.
- W2013359545 cites W2029229178 @default.
- W2013359545 cites W2030205627 @default.
- W2013359545 cites W2037795280 @default.
- W2013359545 cites W2047402066 @default.
- W2013359545 cites W2047762719 @default.
- W2013359545 cites W2048174914 @default.
- W2013359545 cites W2052009158 @default.
- W2013359545 cites W2056113620 @default.
- W2013359545 cites W2056498702 @default.
- W2013359545 cites W2065422132 @default.
- W2013359545 cites W2070705691 @default.
- W2013359545 cites W2079086643 @default.
- W2013359545 cites W2082670534 @default.
- W2013359545 cites W2086667283 @default.
- W2013359545 cites W2094704247 @default.
- W2013359545 cites W2111464898 @default.
- W2013359545 cites W2111584592 @default.
- W2013359545 cites W2122113931 @default.
- W2013359545 cites W2130632774 @default.
- W2013359545 cites W2146008698 @default.
- W2013359545 cites W2153206087 @default.
- W2013359545 cites W2154543554 @default.
- W2013359545 cites W2164191009 @default.
- W2013359545 cites W2165005697 @default.
- W2013359545 cites W4246077736 @default.
- W2013359545 doi "https://doi.org/10.1038/cdd.2013.152" @default.
- W2013359545 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3921587" @default.
- W2013359545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24162663" @default.
- W2013359545 hasPublicationYear "2013" @default.
- W2013359545 type Work @default.
- W2013359545 sameAs 2013359545 @default.
- W2013359545 citedByCount "29" @default.
- W2013359545 countsByYear W20133595452014 @default.
- W2013359545 countsByYear W20133595452016 @default.
- W2013359545 countsByYear W20133595452017 @default.
- W2013359545 countsByYear W20133595452018 @default.
- W2013359545 countsByYear W20133595452019 @default.
- W2013359545 countsByYear W20133595452020 @default.
- W2013359545 countsByYear W20133595452021 @default.
- W2013359545 countsByYear W20133595452022 @default.
- W2013359545 countsByYear W20133595452023 @default.
- W2013359545 crossrefType "journal-article" @default.
- W2013359545 hasAuthorship W2013359545A5014354004 @default.
- W2013359545 hasAuthorship W2013359545A5034365665 @default.
- W2013359545 hasAuthorship W2013359545A5050453522 @default.
- W2013359545 hasAuthorship W2013359545A5061330941 @default.
- W2013359545 hasAuthorship W2013359545A5084800710 @default.
- W2013359545 hasBestOaLocation W20133595451 @default.
- W2013359545 hasConcept C126322002 @default.
- W2013359545 hasConcept C139770010 @default.
- W2013359545 hasConcept C151077648 @default.
- W2013359545 hasConcept C169760540 @default.
- W2013359545 hasConcept C170493617 @default.
- W2013359545 hasConcept C184389661 @default.
- W2013359545 hasConcept C185592680 @default.
- W2013359545 hasConcept C203014093 @default.
- W2013359545 hasConcept C25498285 @default.
- W2013359545 hasConcept C2776914184 @default.
- W2013359545 hasConcept C2778938600 @default.
- W2013359545 hasConcept C2779491297 @default.
- W2013359545 hasConcept C2779830541 @default.
- W2013359545 hasConcept C2781063702 @default.
- W2013359545 hasConcept C29730261 @default.
- W2013359545 hasConcept C55493867 @default.
- W2013359545 hasConcept C62478195 @default.
- W2013359545 hasConcept C71924100 @default.
- W2013359545 hasConcept C86803240 @default.
- W2013359545 hasConcept C88016717 @default.