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• W2013362910 abstract "Twin studies and large-scale population studies have confirmed an increased sibling risk for both Crohn’s disease (CD) and ulcerative colitis (UC). Unlike single gene disorders, CD and UC are thought to result from a complex interplay of multiple genes and environmental factors. The confirmation of <i>CARD15/NOD2</i> as a CD susceptibility gene in the late 1990s caused much excitement in the field of complex diseases in general and since then, the rapid rate of progress in molecular genetics, with the advent of large-scale affordable genotyping techniques, has resulted in large collaborations and the identification of over 30 inflammatory bowel disease (IBD)-associated genes. In particular, the importance of the innate immune system has been reaffirmed with the identification of <i>IRGM</i> and <i>ATG16L1 </i>genes in the autophagy pathway as CD susceptibility genes. Disturbance in the adaptive immune system, in particular the IL-23/Th17 axis, has also shown to be of importance for IBD overall. In this era of genome-wide association studies it may be possible to, at last, identify the multiple genes involved in IBD and thus improve our understanding of the genotype-phenotype correlation and improve treatment." @default.
• W2013362910 created "2016-06-24" @default.
• W2013362910 creator A5064128158 @default.
• W2013362910 creator A5064989585 @default.
• W2013362910 date "2009-01-01" @default.
• W2013362910 modified "2023-09-23" @default.
• W2013362910 title "The Genetic Basis of Inflammatory Bowel Disease" @default.
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