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- W2013367511 abstract "Abstract The enantiodivergent synthesis of polyhydroxylated pyrrolizidines has been achieved, starting from common intermediate 1. The synthesis involved the stereoselective construction of the pyrrolizidine core unit by using intramolecular Michael cyclization reaction as the key reaction. The synthesized eight isomers were evaluated for various glycosidase inhibition effects. Compound 15 showed a moderate inhibitory activity against α- l -fucosidase and a high selectivity compared from the other glycosidases." @default.
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- W2013367511 date "2015-01-01" @default.
- W2013367511 modified "2023-09-25" @default.
- W2013367511 title "Enantiodivergent strategy for the synthesis of polyhydroxylated pyrrolizidines and evaluation of their inhibitory activities against glycosidases" @default.
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- W2013367511 doi "https://doi.org/10.1016/j.tetlet.2014.11.087" @default.
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