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- W2013373526 abstract "Purpose of review HIV-1 mucosal transmission plays a critical role in HIV-1 infection and AIDS pathogenesis. This review summarizes the latest advances in biological studies of HIV-1 mucosal transmission, highlighting the implications of these studies in the development of microbicides to prevent HIV-1 transmission. Recent findings New studies of initial HIV-1 infection using improved culture models updated the current view of mucosal transmission. Mechanistic studies enhanced our understanding of cell–cell transmission of HIV-1 mediated by the major target cells, including dendritic cells, CD4+ T cells, and macrophages. Increasing evidence indicated the significance of host factors and immune responses in HIV-1 mucosal infection and transmission. Summary Recent progress in HIV-1 mucosal infection and transmission enriches our knowledge of virus–host interactions and viral pathogenesis. Functional studies of HIV-1 interactions with host cells can provide new insights into the design of more effective approaches to combat HIV-1 infection and AIDS." @default.
- W2013373526 created "2016-06-24" @default.
- W2013373526 creator A5035457290 @default.
- W2013373526 date "2008-09-01" @default.
- W2013373526 modified "2023-10-09" @default.
- W2013373526 title "Biology of HIV mucosal transmission" @default.
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- W2013373526 doi "https://doi.org/10.1097/coh.0b013e32830634c6" @default.
- W2013373526 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2542876" @default.
- W2013373526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18802490" @default.
- W2013373526 hasPublicationYear "2008" @default.
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