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• W2013373554 abstract "Abstract The neurotransmitter serotonin is synthesized in the retina by one type of amacrine neuron but accumulates in bipolar neurons in many vertebrates. The mechanisms, functions and purpose underlying serotonin accumulation in bipolar cells remain unknown. Here, we demonstrate that exogenous serotonin transiently accumulates in a distinct type of bipolar neuron. KCl‐mediated depolarization causes the depletion of serotonin from amacrine neurons and, subsequently, serotonin is taken‐up by bipolar neurons. The accumulation of endogenous and exogenous serotonin by bipolar neurons is blocked by selective reuptake inhibitors. Exogenous serotonin is specifically taken‐up by bipolar neurons even when serotonin‐synthesizing amacrine neurons are destroyed; excluding the possibility that serotonin diffuses through gap junctions from amacrine into bipolar neurons. Further, inhibition of monoamine oxidase A prevents the degradation of serotonin in bipolar neurons, suggesting that monoamine oxidase A is present in these neurons. However, the vesicular monoamine transporter 2 is present only in amacrine cells suggesting that serotonin is not transported into synaptic vesicles and reused as a transmitter in the bipolar neurons. We conclude that the serotonin‐accumulating bipolar neurons perform glial functions in the retina by actively transporting and degrading serotonin that is synthesized in neighboring amacrine cells." @default.
• W2013373554 created "2016-06-24" @default.
• W2013373554 creator A5021315478 @default.
• W2013373554 creator A5037828663 @default.
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• W2013373554 date "2009-09-14" @default.
• W2013373554 modified "2023-10-18" @default.
• W2013373554 title "Serotonin released from amacrine neurons is scavenged and degraded in bipolar neurons in the retina" @default.
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• W2013373554 doi "https://doi.org/10.1111/j.1471-4159.2009.06270.x" @default.
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