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• W2013373615 abstract "Formation of a flat beta-sheet is a fundamental event in beta-sheet-mediated protein self-assembly. To investigate the contributions of various factors to the stability of flat beta-sheets, we performed extensive alanine-scanning mutagenesis experiments on the single-layer beta-sheet segment of Borrelia outer surface protein A (OspA). This beta-sheet segment consists of beta-strands with highly regular geometries that can serve as a building block for self-assembly. Our Ala-scanning approach is distinct from the conventional host-guest method, in that it introduces only conservative, truncation mutations that should minimize structural perturbation. Our results showed very weak correlation with experimental beta-sheet propensity scales, statistical beta-sheet propensity scales, or cross-strand pairwise correlations. In contrast, our data showed strong positive correlation with the change in buried non-polar surface area. Polar interactions including prominent Glu-Lys cross-strand pairs contribute marginally to the beta-sheet stability. These results were corroborated by results from additional non-Ala mutations. Taken together, these results demonstrate the dominant contribution of non-polar surface burial to flat beta-sheet stability even at solvent-exposed positions. The OspA single-layer beta-sheet achieves efficient hydrophobic surface burial without forming a hydrophobic core by a strategic placement of a variety of side-chains. These findings further suggest the importance of hydrophobic interactions within a beta-sheet layer in peptide self-assembly." @default.
• W2013373615 created "2016-06-24" @default.
• W2013373615 creator A5025990557 @default.
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• W2013373615 creator A5085124300 @default.
• W2013373615 creator A5088513476 @default.
• W2013373615 date "2007-04-01" @default.
• W2013373615 modified "2023-09-26" @default.
• W2013373615 title "Hydrophobic Surface Burial Is the Major Stability Determinant of a Flat, Single-layer β-Sheet" @default.
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• W2013373615 doi "https://doi.org/10.1016/j.jmb.2007.02.003" @default.
• W2013373615 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1995161" @default.
• W2013373615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17335845" @default.
• W2013373615 hasPublicationYear "2007" @default.
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