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• W2013374236 startingPage "2175" @default.
• W2013374236 abstract "The synthesis of tetracyclic quinones 10a,b, 14a,b, 19a,b and 20a,b is described. The preparations involve regioselective Diels-Alder reactions via trapping the thiazole o-quinodimethane 9 with several benzofuranquinones and benzothiophenequinones. The structure of the regioisomers was assigned through 2D NMR 1H-13C HMBC experiments performed on 10a and 14a. Compounds 10a,b, 14a as well as phenol 1 and the starting quinones 2, 5, 7 and 15 are evaluated against Leishmania sp., Toxoplasma gondii and THP-1 cells. Almost all the tested compounds exhibit significant antiprotozoal activities with lower cytotoxicities than the reference compounds. Among them, quinones 2 and 14a possess the best activities towards L. donovani and T. gondii with the lowest toxicities." @default.
• W2013374236 created "2016-06-24" @default.
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• W2013374236 date "2003-05-01" @default.
• W2013374236 modified "2023-10-18" @default.
• W2013374236 title "Synthesis and antiprotozoal activity of naphthofuranquinones and naphthothiophenequinones containing a fused thiazole ring" @default.
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• W2013374236 doi "https://doi.org/10.1016/s0968-0896(03)00122-6" @default.
• W2013374236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12713827" @default.
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