FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013375122> ?p ?o ?g. }

• W2013375122 endingPage "586" @default.
• W2013375122 startingPage "577" @default.
• W2013375122 abstract "Protease-activated receptor-1 (PAR-1) is widely distributed in platelets and involved in coagulation cascade activated by thrombin. In this study, we intend to explore the role of PAR-1 in the process of thrombin-inducing transforming growth factor-β1 (TGF-β1) to promote airway remodeling in ovalbumin (OVA)-allergic rats.A rat model of chronic asthma was set up by systemic sensitization and repeated challenge to OVA. The doses of thrombin, recombinant hirudin, PAR-1 inhibitor ER-112780-06 varied for different groups. We evaluated the bronchoalveolar lavage fluid (BALF) concentration of thrombin in these groups. The protein and gene expression of PAR-1 was assessed and the expression of TGF-β1 was also detected.The PAR-1 mRNA level and the protein level were higher in the airway of asthmatic rats than those of normal rats, and were significantly increased by thrombin treatment but decreased by thrombin-inhibitor treatment. Airway remodeling was strengthened by thrombin but weakened by thrombin inhibitor and PAR-1 antagonist. Expression of TGF-β1 protein in asthmatic rats was significantly increased by thrombin treatment and decreased by thrombin-inhibitor treatment and PAR-1 antagonist treatment.The expression of PAR-1 is regulated by thrombin that induces the expression of TGF-β1 to promote airway remodeling via PAR-1 in OVA-allergic rats." @default.
• W2013375122 created "2016-06-24" @default.
• W2013375122 creator A5003820823 @default.
• W2013375122 creator A5009318195 @default.
• W2013375122 creator A5013736647 @default.
• W2013375122 creator A5018073672 @default.
• W2013375122 creator A5018863416 @default.
• W2013375122 creator A5042384332 @default.
• W2013375122 creator A5055843995 @default.
• W2013375122 creator A5056977572 @default.
• W2013375122 creator A5061696076 @default.
• W2013375122 creator A5067414232 @default.
• W2013375122 creator A5088047550 @default.
• W2013375122 date "2013-08-01" @default.
• W2013375122 modified "2023-10-16" @default.
• W2013375122 title "Thrombin promotes airway remodeling via protease-activated receptor-1 and transforming growth factor-β1 in ovalbumin-allergic rats" @default.
• W2013375122 cites W1543363101 @default.
• W2013375122 cites W1604184306 @default.
• W2013375122 cites W1658287483 @default.
• W2013375122 cites W1795031534 @default.
• W2013375122 cites W1811402656 @default.
• W2013375122 cites W1861812628 @default.
• W2013375122 cites W1925944872 @default.
• W2013375122 cites W1958081034 @default.
• W2013375122 cites W1963938486 @default.
• W2013375122 cites W1964499190 @default.
• W2013375122 cites W1975878833 @default.
• W2013375122 cites W1981419554 @default.
• W2013375122 cites W1983439460 @default.
• W2013375122 cites W1983546035 @default.
• W2013375122 cites W1983625023 @default.
• W2013375122 cites W1988254210 @default.
• W2013375122 cites W1990381860 @default.
• W2013375122 cites W1995511753 @default.
• W2013375122 cites W1997921301 @default.
• W2013375122 cites W2000708019 @default.
• W2013375122 cites W2000754435 @default.
• W2013375122 cites W2004320934 @default.
• W2013375122 cites W2004902531 @default.
• W2013375122 cites W2007664302 @default.
• W2013375122 cites W2013650052 @default.
• W2013375122 cites W2015789566 @default.
• W2013375122 cites W2029622575 @default.
• W2013375122 cites W2031134755 @default.
• W2013375122 cites W2035731160 @default.
• W2013375122 cites W2036706758 @default.
• W2013375122 cites W2040279779 @default.
• W2013375122 cites W2040859108 @default.
• W2013375122 cites W2042146298 @default.
• W2013375122 cites W2043526402 @default.
• W2013375122 cites W2049750246 @default.
• W2013375122 cites W2051719111 @default.
• W2013375122 cites W2060277291 @default.
• W2013375122 cites W2091963274 @default.
• W2013375122 cites W2094671428 @default.
• W2013375122 cites W2099959232 @default.
• W2013375122 cites W2104810826 @default.
• W2013375122 cites W2105998191 @default.
• W2013375122 cites W2110869240 @default.
• W2013375122 cites W2125252801 @default.
• W2013375122 cites W2127667687 @default.
• W2013375122 cites W2131024302 @default.
• W2013375122 cites W2137763236 @default.
• W2013375122 cites W2145697284 @default.
• W2013375122 cites W2159487576 @default.
• W2013375122 cites W2163075092 @default.
• W2013375122 cites W2167351713 @default.
• W2013375122 cites W2167669406 @default.
• W2013375122 doi "https://doi.org/10.3109/08958378.2013.813995" @default.
• W2013375122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23937416" @default.
• W2013375122 hasPublicationYear "2013" @default.
• W2013375122 type Work @default.
• W2013375122 sameAs 2013375122 @default.
• W2013375122 citedByCount "17" @default.
• W2013375122 countsByYear W20133751222013 @default.
• W2013375122 countsByYear W20133751222014 @default.
• W2013375122 countsByYear W20133751222015 @default.
• W2013375122 countsByYear W20133751222016 @default.
• W2013375122 countsByYear W20133751222017 @default.
• W2013375122 countsByYear W20133751222018 @default.
• W2013375122 countsByYear W20133751222022 @default.
• W2013375122 crossrefType "journal-article" @default.
• W2013375122 hasAuthorship W2013375122A5003820823 @default.
• W2013375122 hasAuthorship W2013375122A5009318195 @default.
• W2013375122 hasAuthorship W2013375122A5013736647 @default.
• W2013375122 hasAuthorship W2013375122A5018073672 @default.
• W2013375122 hasAuthorship W2013375122A5018863416 @default.
• W2013375122 hasAuthorship W2013375122A5042384332 @default.
• W2013375122 hasAuthorship W2013375122A5055843995 @default.
• W2013375122 hasAuthorship W2013375122A5056977572 @default.
• W2013375122 hasAuthorship W2013375122A5061696076 @default.
• W2013375122 hasAuthorship W2013375122A5067414232 @default.
• W2013375122 hasAuthorship W2013375122A5088047550 @default.
• W2013375122 hasConcept C118131993 @default.
• W2013375122 hasConcept C125268873 @default.
• W2013375122 hasConcept C126322002 @default.
• W2013375122 hasConcept C134018914 @default.
• W2013375122 hasConcept C170493617 @default.

• next