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- W2013380043 abstract "The mammalian C-type serum lectin, mannan-binding protein (MBP), may induce Clq- and antibody-independent activation of the classical pathway of complement. Accordingly, MBP is considered as a member of the complement system. Complement deficiencies have been found with increased frequency in patients with meningococcal disease. Therefore, we investigated the MBP levels in patients with meningococcal disease. Ninety-nine Norwegian individuals (age 12–21 years) who survived severe systemic disease caused by serogroup B or C meningococci were investigated. No significant differences were observed in the MBP concentration between patients with serogroup B (n = 76) or C (n = 25) disease and healthy blood donor controls (n = 40) (P >0.05). The frequency of patients with low levels of MBP (< 100 μg/1) was 10.1%. This was not different from controls (12.5%). Thus, low MBP concentrations do not appear to predispose to serogroup B or C meningococcal disease." @default.
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- W2013380043 date "1993-04-01" @default.
- W2013380043 modified "2023-10-14" @default.
- W2013380043 title "A Low Serum Concentration of Mannan-Binding Protein is Not Associated with Serogroup B or C Meningococcal Disease" @default.
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- W2013380043 doi "https://doi.org/10.1111/j.1365-3083.1993.tb03320.x" @default.
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