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• W2013380723 abstract "Human leukocyte antigen (HLA) genes play a critical role in host immunity, including vaccine responses. HLA molecules present antigenic peptides to T cells and provide inhibitory signals to NK cells, and polymorphisms within HLA genes allow binding and presentation of a diverse array of self and foreign peptides. Heterozygosity across HLA alleles has been found to play a positive role in host defense for a variety of infections. Homozygosity within one or more HLA loci may restrict this epitope repertoire and limit T-cell responses to infection or vaccination. Here we report that homozygosity within the HLA DPB1 locus is associated with increased levels of rubella-specific IgG, an effect driven by a common allele DPB1*0401. We also show that homozygosity within different HLA class I and class II loci is correlated with variations (but not necessarily decreases) in interleukin (IL)-2, IL-5, and IL-10 secretion after rubella virus stimulation." @default.
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• W2013380723 date "2010-02-01" @default.
• W2013380723 modified "2023-10-08" @default.
• W2013380723 title "Effect of human leukocyte antigen homozygosity on rubella vaccine–induced humoral and cell-mediated immune responses" @default.
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• W2013380723 doi "https://doi.org/10.1016/j.humimm.2009.11.002" @default.
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