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• W2013380922 abstract "In anaesthetised rats, 63 raphe-spinal units in nucleus raphe magnus (NRM) have been identified by means of electrophysiological methods and further classified into serotonergic (5-HT) and non-5-HT units according to their conduction velocity and spontaneous discharge rate. All units, except one, showed either excitatory (n = 39) or inhibitory (n = 23) responses to noxious heating of the tail with hot water at 52°C. The threshold temperature was around 44°C and both types of responses increased with stepwise increases in temperature. The excitatory or inhibitory responses of raphe-spinal units induced by noxious heating of the tail correlated well with those elicited by noxious pinching, but did not correlate with the different transmitter populations (5-HT or non-5-HT) of the NRM unit. The effects of morphine or Fentanyl administration on the heat-induced responses of NRM units was observed. The possible involvement of NRM raphe-spinal units in ‘diffuse noxious inhibitory controls’ (DNICs) was discussed, particularly in relation to the ‘lifting of DNICs’ produced by morphine." @default.
• W2013380922 created "2016-06-24" @default.
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• W2013380922 date "1986-08-01" @default.
• W2013380922 modified "2023-10-15" @default.
• W2013380922 title "The modification by systemic morphine of the responses of serotonergic and non-serotonergic neurons in nucleus raphe magnus to heating the tail" @default.
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• W2013380922 doi "https://doi.org/10.1016/0304-3959(86)90079-5" @default.
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