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• W2013382016 abstract "Abstract The effect of additives (surfactants and polymers) and pH on the clouding behavior of promethazine hydrochloride (PMT, a phenothiazine drug) was investigated. Cloud point (CP) decreases with increase in pH due to deprotonation of drug molecules. The same trend occurs in the presence of surfactants. However, at constant pH, and depending on their structure and nature, these additives behave differently. Anionic surfactants show peaked behavior, whereas cationic (conventional as well as geminis) and non‐ionic surfactants increase the CP, although the mechanisms differ. Cationic surfactants hinder drug association (due to interaggregate repulsion) resulting in an increase in CP, while non‐ionic surfactants form mixed micelles with the drug, increasing micelle hydration and CP. Polymers can cause both a decrease as well as an increase in CP, depending on their molecular weight. A large CP increase (with the increase in surfactant concentration) for gemini surfactants suggests they are excellent candidates for drug delivery." @default.
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• W2013382016 date "2007-01-19" @default.
• W2013382016 modified "2023-10-16" @default.
• W2013382016 title "Tuning of the Cloud Point of Promethazine Hydrochloride with Surfactants and Polymers" @default.
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• W2013382016 doi "https://doi.org/10.1007/s11743-006-1008-0" @default.
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