Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013383275> ?p ?o ?g. }
- W2013383275 endingPage "460" @default.
- W2013383275 startingPage "449" @default.
- W2013383275 abstract "Tau is a microtubule-associated protein mainly expressed in neurons of central nervous system, which is crucial in the maintenance of these cells. It has a central role in the polymerization and stabilization of microtubules and in the traffic of organelles along axons and dendrites. Aggregates of hyperphosphorylated forms of tau protein participate in the formation of neurofibrillary tangles, which characterize numerous neurodegenerative disorders named tauopathies. The analysis of tau gene and the study of familial cases of tauopathies have led to the discovery of tau gene mutations that cause inherited dementia designated as Frontotemporal dementia (FTD) with parkinsonism linked to chromosome 17 (FTDP-17). However, these familial cases remain rare compared to the sporadic tauopathies, the later involving both genetic and environmental etiologic factors. As tau pathology represents a primary pathogenic event in various neurodegenerative diseases, the hypothesis that tau genotype could influence the development of these diseases was tested by several groups. This review summarizes advances in the molecular genetics of the tau gene, as well as recent studies addressing the disease incidence of novel tau polymorphisms in different neurodegenerative diseases. Hopefully, the identification of several genetic defects of the tau gene will be helpful in improving our understanding of the role of tau protein in the pathogenesis of various neurodegenerative diseases." @default.
- W2013383275 created "2016-06-24" @default.
- W2013383275 creator A5000431138 @default.
- W2013383275 creator A5015075499 @default.
- W2013383275 creator A5045746050 @default.
- W2013383275 creator A5069703695 @default.
- W2013383275 date "2004-04-01" @default.
- W2013383275 modified "2023-10-16" @default.
- W2013383275 title "Microtubule-associated protein tau gene: a risk factor in human neurodegenerative diseases" @default.
- W2013383275 cites W110345006 @default.
- W2013383275 cites W1487083411 @default.
- W2013383275 cites W1511517753 @default.
- W2013383275 cites W1527671059 @default.
- W2013383275 cites W1561023982 @default.
- W2013383275 cites W1600934558 @default.
- W2013383275 cites W1618846043 @default.
- W2013383275 cites W1877873625 @default.
- W2013383275 cites W1964234174 @default.
- W2013383275 cites W1964714401 @default.
- W2013383275 cites W1968641736 @default.
- W2013383275 cites W1968813853 @default.
- W2013383275 cites W1970308747 @default.
- W2013383275 cites W1970600154 @default.
- W2013383275 cites W1971165215 @default.
- W2013383275 cites W1971724395 @default.
- W2013383275 cites W1972553694 @default.
- W2013383275 cites W1972966142 @default.
- W2013383275 cites W1975040221 @default.
- W2013383275 cites W1975321314 @default.
- W2013383275 cites W1975768665 @default.
- W2013383275 cites W1977967681 @default.
- W2013383275 cites W1978400690 @default.
- W2013383275 cites W1979752653 @default.
- W2013383275 cites W1981510818 @default.
- W2013383275 cites W1987844942 @default.
- W2013383275 cites W1992637711 @default.
- W2013383275 cites W1995152171 @default.
- W2013383275 cites W1997709333 @default.
- W2013383275 cites W1998020365 @default.
- W2013383275 cites W2005671109 @default.
- W2013383275 cites W2012733162 @default.
- W2013383275 cites W2016473759 @default.
- W2013383275 cites W2016732319 @default.
- W2013383275 cites W2018260001 @default.
- W2013383275 cites W2018756041 @default.
- W2013383275 cites W2019463406 @default.
- W2013383275 cites W2021181758 @default.
- W2013383275 cites W2022943439 @default.
- W2013383275 cites W2024941524 @default.
- W2013383275 cites W2026852774 @default.
- W2013383275 cites W2029205666 @default.
- W2013383275 cites W2035462700 @default.
- W2013383275 cites W2037481987 @default.
- W2013383275 cites W2039352533 @default.
- W2013383275 cites W2040746517 @default.
- W2013383275 cites W2041880442 @default.
- W2013383275 cites W2045220210 @default.
- W2013383275 cites W2045671840 @default.
- W2013383275 cites W2045857789 @default.
- W2013383275 cites W2046780896 @default.
- W2013383275 cites W2046972756 @default.
- W2013383275 cites W2047080490 @default.
- W2013383275 cites W2051455922 @default.
- W2013383275 cites W2053652338 @default.
- W2013383275 cites W2054684018 @default.
- W2013383275 cites W2054747116 @default.
- W2013383275 cites W2057796532 @default.
- W2013383275 cites W2058562556 @default.
- W2013383275 cites W2060382205 @default.
- W2013383275 cites W2064244929 @default.
- W2013383275 cites W2065032350 @default.
- W2013383275 cites W2068689018 @default.
- W2013383275 cites W2083219512 @default.
- W2013383275 cites W2084078835 @default.
- W2013383275 cites W2086334629 @default.
- W2013383275 cites W2086787068 @default.
- W2013383275 cites W2088185367 @default.
- W2013383275 cites W2089364726 @default.
- W2013383275 cites W2090197378 @default.
- W2013383275 cites W2090645563 @default.
- W2013383275 cites W2092754504 @default.
- W2013383275 cites W2094922227 @default.
- W2013383275 cites W2098131816 @default.
- W2013383275 cites W2107356311 @default.
- W2013383275 cites W2111567107 @default.
- W2013383275 cites W2113507118 @default.
- W2013383275 cites W2117526022 @default.
- W2013383275 cites W2118544659 @default.
- W2013383275 cites W2118629228 @default.
- W2013383275 cites W2121718017 @default.
- W2013383275 cites W2126264983 @default.
- W2013383275 cites W2135439793 @default.
- W2013383275 cites W2139304769 @default.
- W2013383275 cites W2139933719 @default.
- W2013383275 cites W2141839336 @default.
- W2013383275 cites W2142326012 @default.
- W2013383275 cites W2143604549 @default.
- W2013383275 cites W2144122379 @default.