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- W2013387316 abstract "To the Editor.— Rodger (217:1705, 1971) mentioned a not widely known cardiac action of an extract of Cannabis roots in whiskey (about 45% alcohol). We report here our experiments on the supposed action of these roots in 50% alcohol, diluted to 18.4 mg/ml in 4% ethanol in water. This solution contained 18.4 mg dry substance/ml. This was injected in the perfusion fluid of an isolated guinea pig heart in vitro (Langendorff technique). Injection of 0.1 ml of the preparation was followed by bradycardia; the rate dropped from 240 beats/minute to 60 beats/minute. A quick recovery was seen when administration was stopped. In our next experiment we studied the effect of root extract on the electrocardiogram of three guinea pigs under urethane anesthesia. The preparation was infused in the jugular vein at the rate of 0.2 ml/min. After some time bradycardia developed with prolongation of the PR interval and the QRS" @default.
- W2013387316 created "2016-06-24" @default.
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- W2013387316 date "1973-07-30" @default.
- W2013387316 modified "2023-10-14" @default.
- W2013387316 title "Effects of Cannabis roots on the heart" @default.
- W2013387316 doi "https://doi.org/10.1001/jama.225.5.525b" @default.
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