Matches in SemOpenAlex for { <https://semopenalex.org/work/W201339084> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W201339084 endingPage "3" @default.
- W201339084 startingPage "4391" @default.
- W201339084 abstract "Matrix metalloproteinases (MMPs) are a family of zinc-dependent metalloendopeptidases which participate in the degradation of collagen and other extracellular matrix macromolecules. Expression of gelatonic MMPs, such as MMP-2 has been linked to enhanced tumor invasion and metastases in in vitro and in vivo model systems. It was the aim of this study to determine whether the expression of MMP-1, MMP-2, and TIMP-2 correlates with survival in patients with surgically treated cervical cancer stage IB.A sample of 154 paraffin-embedded tumor specimens of surgical treated FIGO stage IB cervical cancer was immunohistochemically investigated.MMP-1, MMP-2, and TIMP-2 were detected by immunohistochemistry in 74% (113/154), 32% (49/154), and 80% (107/154) of the tumor samples, respectively. Correlation coefficients for MMP-1/MMP-2, MMP-1/TIMP-2, MMP-2/TIMP-2 were 0.14 (p = 0.12), 0.37 (p = 0.0001), and 0.17 (p: 0.005), respectively. A significant correlation was found between MMP-1 and lymph node status (P < 0.01) and lymphvascular space invasion (P < 0.05). The expression of MMP-1 (log-rank test, p = 0.6), MMP-2 (log-rank test, p = 0.8), and TIMP-2 (log-rank test, p = 0.15) were not correlated with overall survival.MMP-1, detected by immunohistochemistry, seems to play a role in the development of lymphvascular space invasion and lymph node metastases, but is not helpful in predicting the prognosis of cervical cancer patients." @default.
- W201339084 created "2016-06-24" @default.
- W201339084 creator A5000180375 @default.
- W201339084 creator A5013439619 @default.
- W201339084 creator A5054843736 @default.
- W201339084 creator A5071232358 @default.
- W201339084 creator A5072413741 @default.
- W201339084 creator A5072669776 @default.
- W201339084 date "2000-01-29" @default.
- W201339084 modified "2023-09-29" @default.
- W201339084 title "Immunohistochemical detection of matrix metalloproteinases (MMP) 1 and 2, and tissue inhibitor of metalloproteinase 2 (TIMP 2) in stage IB cervical cancer." @default.
- W201339084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10650781" @default.
- W201339084 hasPublicationYear "2000" @default.
- W201339084 type Work @default.
- W201339084 sameAs 201339084 @default.
- W201339084 citedByCount "16" @default.
- W201339084 countsByYear W2013390842012 @default.
- W201339084 countsByYear W2013390842013 @default.
- W201339084 countsByYear W2013390842017 @default.
- W201339084 countsByYear W2013390842021 @default.
- W201339084 crossrefType "journal-article" @default.
- W201339084 hasAuthorship W201339084A5000180375 @default.
- W201339084 hasAuthorship W201339084A5013439619 @default.
- W201339084 hasAuthorship W201339084A5054843736 @default.
- W201339084 hasAuthorship W201339084A5071232358 @default.
- W201339084 hasAuthorship W201339084A5072413741 @default.
- W201339084 hasAuthorship W201339084A5072669776 @default.
- W201339084 hasConcept C109523444 @default.
- W201339084 hasConcept C121608353 @default.
- W201339084 hasConcept C126322002 @default.
- W201339084 hasConcept C142724271 @default.
- W201339084 hasConcept C146357865 @default.
- W201339084 hasConcept C151730666 @default.
- W201339084 hasConcept C189165786 @default.
- W201339084 hasConcept C204232928 @default.
- W201339084 hasConcept C2775965246 @default.
- W201339084 hasConcept C2778220009 @default.
- W201339084 hasConcept C2780849966 @default.
- W201339084 hasConcept C71924100 @default.
- W201339084 hasConcept C86803240 @default.
- W201339084 hasConcept C95444343 @default.
- W201339084 hasConceptScore W201339084C109523444 @default.
- W201339084 hasConceptScore W201339084C121608353 @default.
- W201339084 hasConceptScore W201339084C126322002 @default.
- W201339084 hasConceptScore W201339084C142724271 @default.
- W201339084 hasConceptScore W201339084C146357865 @default.
- W201339084 hasConceptScore W201339084C151730666 @default.
- W201339084 hasConceptScore W201339084C189165786 @default.
- W201339084 hasConceptScore W201339084C204232928 @default.
- W201339084 hasConceptScore W201339084C2775965246 @default.
- W201339084 hasConceptScore W201339084C2778220009 @default.
- W201339084 hasConceptScore W201339084C2780849966 @default.
- W201339084 hasConceptScore W201339084C71924100 @default.
- W201339084 hasConceptScore W201339084C86803240 @default.
- W201339084 hasConceptScore W201339084C95444343 @default.
- W201339084 hasIssue "5C" @default.
- W201339084 hasLocation W2013390841 @default.
- W201339084 hasOpenAccess W201339084 @default.
- W201339084 hasPrimaryLocation W2013390841 @default.
- W201339084 hasRelatedWork W201339084 @default.
- W201339084 hasRelatedWork W2073070699 @default.
- W201339084 hasRelatedWork W2125464616 @default.
- W201339084 hasRelatedWork W2341667437 @default.
- W201339084 hasRelatedWork W2349529696 @default.
- W201339084 hasRelatedWork W2356218832 @default.
- W201339084 hasRelatedWork W2383786257 @default.
- W201339084 hasRelatedWork W2400433680 @default.
- W201339084 hasRelatedWork W2413949891 @default.
- W201339084 hasRelatedWork W2467703741 @default.
- W201339084 hasVolume "19" @default.
- W201339084 isParatext "false" @default.
- W201339084 isRetracted "false" @default.
- W201339084 magId "201339084" @default.
- W201339084 workType "article" @default.