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- W2013399757 abstract "The present study was an attempt to elucidate the effect of sex steroids (estradiol-17β and 5α-dihydrotestosterone) on the mitogen-stimulated human peripheral blood lymphocytes (PBL) proliferation. Our findings were as follows: (a) the proliferation of PBL in response to phytohemagglutinin (PHA) was mediated by protein kinase C (PKC) activity, but a strong inhibitory effect of sex steroids on the PKC activity of PHA-stimulated PBL was observed; (b) cytoplasmic extracts of PHA-stimulated PBL showed high activity as an activator of DNA replication (ADR) as well as increased levels of the mitosis stimulator p34cdc2 kinase, and the steroid hormones studied all significantly reduced these activities; and (c) these effects of sex steroids are similar to those found with hydrocortisone in parallel experiments. The results suggest that the cytoplasmic signal-generating system stimulating DNA synthesis and mitosis is inhibited in PHA-stimulated PBLs by several steroid hormones. The inhibition affects different factors stimulating DNA replication and cell proliferation." @default.
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- W2013399757 date "1998-06-01" @default.
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- W2013399757 title "Sex hormones affect the intracellular activation signal in mitogen-stimulated human blood lymphocytes" @default.
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- W2013399757 doi "https://doi.org/10.1016/s0928-4680(97)10012-8" @default.
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