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• W2013403313 endingPage "994" @default.
• W2013403313 startingPage "986" @default.
• W2013403313 abstract "Ageing in mammals remains an unsolved mystery. Anti-ageing is a recurring topic in the history of scientific research. Lifespan extension evoked by Sir2 protein in lower organisms has attracted a large amount of interests in the last decade. This review summarizes recent evidence supporting the role of a Sir2 mammalian homologue, SIRT1 (Silent information regulator T1), in regulating ageing and cellular senescence. The various signaling networks responsible for the anti-ageing and anti-senescence activity of SIRT1 have been discussed. In particular, a counter-balancing model involving the cross-talks between SIRT1 and AMP-activated protein kinase (AMPK), another stress and energy sensor, is suggested for controlling the senescence program in mammalian cells." @default.
• W2013403313 created "2016-06-24" @default.
• W2013403313 creator A5005885490 @default.
• W2013403313 creator A5018541150 @default.
• W2013403313 creator A5022950764 @default.
• W2013403313 date "2010-12-02" @default.
• W2013403313 modified "2023-10-05" @default.
• W2013403313 title "SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model" @default.
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