FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013407554> ?p ?o ?g. }

• W2013407554 endingPage "4363" @default.
• W2013407554 startingPage "4351" @default.
• W2013407554 abstract "The efficiency of metazoan origins of DNA replication is known to be enhanced by histone acetylation near origins. Although this correlates with increased MCM recruitment, the mechanism by which such acetylation regulates MCM loading is unknown. We show here that Cdt1 induces large-scale chromatin decondensation that is required for MCM recruitment. This process occurs in G₁, is suppressed by Geminin, and requires HBO1 HAT activity and histone H4 modifications. HDAC11, which binds Cdt1 and replication origins during S-phase, potently inhibits Cdt1-induced chromatin unfolding and re-replication, suppresses MCM loading and binds Cdt1 more efficiently in the presence of Geminin. We also demonstrate that chromatin at endogenous origins is more accessible in G₁ relative to S-phase. These results provide evidence that histone acetylation promotes MCM loading via enhanced chromatin accessibility. This process is regulated positively by Cdt1 and HBO1 in G₁ and repressed by Geminin-HDAC11 association with Cdt1 in S-phase, and represents a novel form of replication licensing control." @default.
• W2013407554 created "2016-06-24" @default.
• W2013407554 creator A5004256523 @default.
• W2013407554 creator A5046474582 @default.
• W2013407554 creator A5057898271 @default.
• W2013407554 creator A5065629573 @default.
• W2013407554 creator A5068995661 @default.
• W2013407554 creator A5077967189 @default.
• W2013407554 date "2010-11-01" @default.
• W2013407554 modified "2023-10-12" @default.
• W2013407554 title "Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin" @default.
• W2013407554 cites W1971377179 @default.
• W2013407554 cites W1975228929 @default.
• W2013407554 cites W1977180757 @default.
• W2013407554 cites W1985845937 @default.
• W2013407554 cites W1987465149 @default.
• W2013407554 cites W2000625991 @default.
• W2013407554 cites W2001591980 @default.
• W2013407554 cites W2002466684 @default.
• W2013407554 cites W2002698073 @default.
• W2013407554 cites W2011180717 @default.
• W2013407554 cites W2014463884 @default.
• W2013407554 cites W2017816163 @default.
• W2013407554 cites W2017852552 @default.
• W2013407554 cites W2021659807 @default.
• W2013407554 cites W2027639574 @default.
• W2013407554 cites W2029925140 @default.
• W2013407554 cites W2036111506 @default.
• W2013407554 cites W2036920293 @default.
• W2013407554 cites W2045631017 @default.
• W2013407554 cites W2048464448 @default.
• W2013407554 cites W2048620098 @default.
• W2013407554 cites W2053437887 @default.
• W2013407554 cites W2059594509 @default.
• W2013407554 cites W2061481911 @default.
• W2013407554 cites W2065971145 @default.
• W2013407554 cites W2067368224 @default.
• W2013407554 cites W2069328568 @default.
• W2013407554 cites W2070089404 @default.
• W2013407554 cites W2074637369 @default.
• W2013407554 cites W2084680530 @default.
• W2013407554 cites W2090381051 @default.
• W2013407554 cites W2094296110 @default.
• W2013407554 cites W2095934571 @default.
• W2013407554 cites W2097088500 @default.
• W2013407554 cites W2106130068 @default.
• W2013407554 cites W2108654668 @default.
• W2013407554 cites W2112642897 @default.
• W2013407554 cites W2115314080 @default.
• W2013407554 cites W2117108225 @default.
• W2013407554 cites W2133158696 @default.
• W2013407554 cites W2134629510 @default.
• W2013407554 cites W2138165389 @default.
• W2013407554 cites W2138533207 @default.
• W2013407554 cites W2140594545 @default.
• W2013407554 cites W2142614409 @default.
• W2013407554 cites W2148939895 @default.
• W2013407554 cites W2151485619 @default.
• W2013407554 cites W2154071588 @default.
• W2013407554 cites W2160193607 @default.
• W2013407554 cites W2164031201 @default.
• W2013407554 doi "https://doi.org/10.4161/cc.9.21.13596" @default.
• W2013407554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3055186" @default.
• W2013407554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20980834" @default.
• W2013407554 hasPublicationYear "2010" @default.
• W2013407554 type Work @default.
• W2013407554 sameAs 2013407554 @default.
• W2013407554 citedByCount "59" @default.
• W2013407554 countsByYear W20134075542012 @default.
• W2013407554 countsByYear W20134075542013 @default.
• W2013407554 countsByYear W20134075542014 @default.
• W2013407554 countsByYear W20134075542015 @default.
• W2013407554 countsByYear W20134075542016 @default.
• W2013407554 countsByYear W20134075542017 @default.
• W2013407554 countsByYear W20134075542018 @default.
• W2013407554 countsByYear W20134075542019 @default.
• W2013407554 countsByYear W20134075542020 @default.
• W2013407554 countsByYear W20134075542021 @default.
• W2013407554 countsByYear W20134075542022 @default.
• W2013407554 countsByYear W20134075542023 @default.
• W2013407554 crossrefType "journal-article" @default.
• W2013407554 hasAuthorship W2013407554A5004256523 @default.
• W2013407554 hasAuthorship W2013407554A5046474582 @default.
• W2013407554 hasAuthorship W2013407554A5057898271 @default.
• W2013407554 hasAuthorship W2013407554A5065629573 @default.
• W2013407554 hasAuthorship W2013407554A5068995661 @default.
• W2013407554 hasAuthorship W2013407554A5077967189 @default.
• W2013407554 hasBestOaLocation W20134075541 @default.
• W2013407554 hasConcept C104317684 @default.
• W2013407554 hasConcept C119157956 @default.
• W2013407554 hasConcept C151158763 @default.
• W2013407554 hasConcept C175193931 @default.
• W2013407554 hasConcept C2779085176 @default.
• W2013407554 hasConcept C502942594 @default.
• W2013407554 hasConcept C54355233 @default.
• W2013407554 hasConcept C552990157 @default.
• W2013407554 hasConcept C64927066 @default.
• W2013407554 hasConcept C73573662 @default.

• next