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• W2013408095 abstract "Lycopene β-cyclase ( tlcy-b ) tomatoes, obtained by modulating carotenogenesis via genetic engineering, contain a large amount of β-carotene, as clearly visible by their intense orange colour. In the present study we have subjected tlcy-b tomatoes to an in vitro simulated digestion and analysed the effects of digestate on cell proliferation. To this aim we used HT-29 human colon adenocarcinoma cells, grown in monolayers, as a model. Digested tomatoes were diluted (20 ml, 50 ml and 100 ml/l) in culture medium and added to the cells for different incubation times (24 h, 48 h and 72 h). Inhibition of cell growth by tomato digestate was dose-dependent and resulted from an arrest of cell cycle progression at the G0/G1 and G2/M phase and by apoptosis induction. A down-regulation of cyclin D1, Bcl-2 and Bcl-xl expression was observed. We also found that heat treatment of samples before digestion enhanced β-carotene release and therefore cell growth inhibition. To induce with purified β-carotene solubilised in tetrahydrofuran the same cell growth inhibition obtained with the tomato digestate, a higher amount of the carotenoid was necessary, suggesting that β-carotene micellarised during digestion is utilised more efficiently by the cells, but also that other tomato molecules, reasonably made available during digestion, may be present and cooperate with β-carotene in promoting cell growth arrest." @default.
• W2013408095 created "2016-06-24" @default.
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• W2013408095 date "2008-12-24" @default.
• W2013408095 modified "2023-10-14" @default.
• W2013408095 title "Effect of β-carotene-rich tomato lycopene β-cyclase (<i>tlcy-b</i>) on cell growth inhibition in HT-29 colon adenocarcinoma cells" @default.
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• W2013408095 doi "https://doi.org/10.1017/s0007114508169902" @default.
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