FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013409852> ?p ?o ?g. }

• W2013409852 endingPage "28" @default.
• W2013409852 startingPage "22" @default.
• W2013409852 abstract "Methylphenidate (MPH) is a phenethylamine derivative used in the treatment of attention-deficit hyperactivity disorder (ADHD). In adults, clinical monitoring of MPH therapy is usually performed by measuring plasma MPH concentrations. In children blood sampling is however undesirable. Saliva may be an alternative matrix for monitoring MPH concentrations with the advantage that it can be obtained non-invasively. Therefore, we developed an analytical method for the quantification of MPH in both plasma and saliva. We present the validation of a liquid chromatography-tandem mass spectrometric method using a hydrophilic interaction liquid chromatography column (HILIC). In 100 μL sample, proteins were precipitated with 750 μL acetonitrile/methanol 84/16 (v/v) containing d9-methylphenidate as the internal standard. Standard curves were prepared over the MPH concentration range of 0.5-100.0 μg/L. The total analysis time was 45 s. Accuracy and within- and between-run imprecision were in the range of 98-108% and less than 7.0%, respectively. Matrix effects were greater for plasma than saliva with 46% and 8% ionization suppression. The matrix effects were adequately compensated by the use of deuterated MPH as internal standard. MPH significantly degraded in plasma and saliva at room temperature and 5°C. Samples were stable at -20°C for at least 4 weeks. The method was successfully applied for the determination of MPH concentrations in plasma and saliva samples from an adult healthy volunteer. Using protein precipitation and hydrophilic interaction liquid chromatography coupled to tandem mass spectrometry, this method allows fast, accurate and precise quantification of MPH in both plasma and saliva." @default.
• W2013409852 created "2016-06-24" @default.
• W2013409852 creator A5011244926 @default.
• W2013409852 creator A5018774955 @default.
• W2013409852 creator A5021986417 @default.
• W2013409852 creator A5027401221 @default.
• W2013409852 creator A5036376468 @default.
• W2013409852 creator A5046229997 @default.
• W2013409852 creator A5077176003 @default.
• W2013409852 creator A5079265856 @default.
• W2013409852 date "2013-04-01" @default.
• W2013409852 modified "2023-10-10" @default.
• W2013409852 title "Determination of methylphenidate in plasma and saliva by liquid chromatography/tandem mass spectrometry" @default.
• W2013409852 cites W1897281761 @default.
• W2013409852 cites W1984217658 @default.
• W2013409852 cites W1997112598 @default.
• W2013409852 cites W1998857835 @default.
• W2013409852 cites W2007728591 @default.
• W2013409852 cites W2011720547 @default.
• W2013409852 cites W2023323019 @default.
• W2013409852 cites W2024290100 @default.
• W2013409852 cites W2032609787 @default.
• W2013409852 cites W2032995175 @default.
• W2013409852 cites W2041346157 @default.
• W2013409852 cites W2041491649 @default.
• W2013409852 cites W2042860672 @default.
• W2013409852 cites W2050226999 @default.
• W2013409852 cites W2051443552 @default.
• W2013409852 cites W2056363043 @default.
• W2013409852 cites W2084139215 @default.
• W2013409852 cites W2091789455 @default.
• W2013409852 cites W2111501560 @default.
• W2013409852 cites W2145626389 @default.
• W2013409852 cites W2147595314 @default.
• W2013409852 cites W2149010247 @default.
• W2013409852 cites W2150897879 @default.
• W2013409852 cites W2161065465 @default.
• W2013409852 cites W2162745202 @default.
• W2013409852 cites W39215153 @default.
• W2013409852 cites W4296404382 @default.
• W2013409852 doi "https://doi.org/10.1016/j.jchromb.2013.01.027" @default.
• W2013409852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23454305" @default.
• W2013409852 hasPublicationYear "2013" @default.
• W2013409852 type Work @default.
• W2013409852 sameAs 2013409852 @default.
• W2013409852 citedByCount "23" @default.
• W2013409852 countsByYear W20134098522013 @default.
• W2013409852 countsByYear W20134098522014 @default.
• W2013409852 countsByYear W20134098522015 @default.
• W2013409852 countsByYear W20134098522016 @default.
• W2013409852 countsByYear W20134098522017 @default.
• W2013409852 countsByYear W20134098522018 @default.
• W2013409852 countsByYear W20134098522019 @default.
• W2013409852 countsByYear W20134098522020 @default.
• W2013409852 countsByYear W20134098522021 @default.
• W2013409852 countsByYear W20134098522022 @default.
• W2013409852 crossrefType "journal-article" @default.
• W2013409852 hasAuthorship W2013409852A5011244926 @default.
• W2013409852 hasAuthorship W2013409852A5018774955 @default.
• W2013409852 hasAuthorship W2013409852A5021986417 @default.
• W2013409852 hasAuthorship W2013409852A5027401221 @default.
• W2013409852 hasAuthorship W2013409852A5036376468 @default.
• W2013409852 hasAuthorship W2013409852A5046229997 @default.
• W2013409852 hasAuthorship W2013409852A5077176003 @default.
• W2013409852 hasAuthorship W2013409852A5079265856 @default.
• W2013409852 hasConcept C106487976 @default.
• W2013409852 hasConcept C116817701 @default.
• W2013409852 hasConcept C162356407 @default.
• W2013409852 hasConcept C179998833 @default.
• W2013409852 hasConcept C185592680 @default.
• W2013409852 hasConcept C31827203 @default.
• W2013409852 hasConcept C43617362 @default.
• W2013409852 hasConcept C504460877 @default.
• W2013409852 hasConcept C55493867 @default.
• W2013409852 hasConcept C64489805 @default.
• W2013409852 hasConcept C74774607 @default.
• W2013409852 hasConceptScore W2013409852C106487976 @default.
• W2013409852 hasConceptScore W2013409852C116817701 @default.
• W2013409852 hasConceptScore W2013409852C162356407 @default.
• W2013409852 hasConceptScore W2013409852C179998833 @default.
• W2013409852 hasConceptScore W2013409852C185592680 @default.
• W2013409852 hasConceptScore W2013409852C31827203 @default.
• W2013409852 hasConceptScore W2013409852C43617362 @default.
• W2013409852 hasConceptScore W2013409852C504460877 @default.
• W2013409852 hasConceptScore W2013409852C55493867 @default.
• W2013409852 hasConceptScore W2013409852C64489805 @default.
• W2013409852 hasConceptScore W2013409852C74774607 @default.
• W2013409852 hasLocation W20134098521 @default.
• W2013409852 hasLocation W20134098522 @default.
• W2013409852 hasOpenAccess W2013409852 @default.
• W2013409852 hasPrimaryLocation W20134098521 @default.
• W2013409852 hasRelatedWork W1968381290 @default.
• W2013409852 hasRelatedWork W1968441093 @default.
• W2013409852 hasRelatedWork W1985085476 @default.
• W2013409852 hasRelatedWork W1985701257 @default.
• W2013409852 hasRelatedWork W2012636341 @default.
• W2013409852 hasRelatedWork W2053390790 @default.
• W2013409852 hasRelatedWork W2185025379 @default.

• next