FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013417438> ?p ?o ?g. }

• W2013417438 endingPage "990" @default.
• W2013417438 startingPage "980" @default.
• W2013417438 abstract "Normal and abnormal extracellular matrix turnover is thought to result, in part, from the balance in the expression of metalloproteinases and tissue inhibitors of metalloproteinases (TIMPs). The clinical manifestations of an imbalance in these relationships are evident in a variety of pathologic states, including osteoarthritis, deficient long-bone growth, rheumatoid arthritis, tumor invasion, and inadequate cartilage repair. Articular cartilage defects commonly heal as fibrocartilage, which is structurally inferior to the normal hyaline architecture of articular cartilage. Transforming growth factor-beta 1 (TGF-beta1), a cytokine central to growth, repair, and inflammation, has been shown to upregulate TIMP-1 expression in human and bovine articular cartilage. Additionally, members of the TGF-beta superfamily are thought to play key roles in chondrocyte growth and differentiation. Bone morphogenetic protein-2 (BMP-2), a member of this superfamily, has been shown to regulate chondrocyte differentiation states and extracellular matrix composition. It was proposed that, by optimizing extracellular matrix composition, BMP-2 would enhance articular cartilage healing. After determining the release kinetics of BMP-2 from a collagen type I implant (Long-Evans male rats; two implants/rat, n = 14), it was found that, in a tissue engineering application, BMP-2 induced a hyaline-like repair of New Zealand White rabbit knee articular cartilage defects (3-mm full-thickness defects in the femoral trochlea; 2 defects/rabbit, n = 36). The quality of cartilage repair with BMP-2 (with or without chondrocytes) was significantly better than defects treated with BMP-2, as assessed by a quantitative scoring scale. Immunohistochemical staining revealed TIMP-1 production in the cartilage defects treated with BMP-2. When studied in vitro, it was found that BMP-2 markedly increased TIMP-1 mRNA by both bovine articular and human rib chondrocytes. Additionally, increased TIMP-1 mRNA was translated into increased TIMP-1 protein production by bovine chondrocytes. Taken together, these data suggest that BMP-2 may be a useful cytokine to improve healing of cartilaginous defects. Furthermore, these data suggest that the beneficial effects of BMP-2 may be, in part, related to alterations in extracellular matrix turnover." @default.
• W2013417438 created "2016-06-24" @default.
• W2013417438 creator A5004508233 @default.
• W2013417438 creator A5005728573 @default.
• W2013417438 creator A5042107654 @default.
• W2013417438 creator A5044556352 @default.
• W2013417438 creator A5046895879 @default.
• W2013417438 creator A5067965341 @default.
• W2013417438 creator A5081956660 @default.
• W2013417438 creator A5085080492 @default.
• W2013417438 date "2000-03-01" @default.
• W2013417438 modified "2023-10-07" @default.
• W2013417438 title "Transforming Growth Factor Beta Superfamily Members: Role in Cartilage Modeling" @default.
• W2013417438 cites W141802151 @default.
• W2013417438 cites W1943677324 @default.
• W2013417438 cites W1946911025 @default.
• W2013417438 cites W1975254706 @default.
• W2013417438 cites W1977837843 @default.
• W2013417438 cites W1978704526 @default.
• W2013417438 cites W1981949250 @default.
• W2013417438 cites W1982183335 @default.
• W2013417438 cites W1982697678 @default.
• W2013417438 cites W1988592246 @default.
• W2013417438 cites W1993950414 @default.
• W2013417438 cites W1996204310 @default.
• W2013417438 cites W2001410834 @default.
• W2013417438 cites W2006691988 @default.
• W2013417438 cites W2014520115 @default.
• W2013417438 cites W2029148411 @default.
• W2013417438 cites W2034058850 @default.
• W2013417438 cites W2047144232 @default.
• W2013417438 cites W2054496091 @default.
• W2013417438 cites W2061798549 @default.
• W2013417438 cites W2063014734 @default.
• W2013417438 cites W2066577371 @default.
• W2013417438 cites W2075219706 @default.
• W2013417438 cites W2077008849 @default.
• W2013417438 cites W2077807026 @default.
• W2013417438 cites W2078164942 @default.
• W2013417438 cites W2094064497 @default.
• W2013417438 cites W2116947669 @default.
• W2013417438 cites W2121848695 @default.
• W2013417438 cites W2143835908 @default.
• W2013417438 cites W2148965620 @default.
• W2013417438 cites W2149463866 @default.
• W2013417438 cites W2409059486 @default.
• W2013417438 cites W2606329721 @default.
• W2013417438 cites W4301152737 @default.
• W2013417438 cites W582067959 @default.
• W2013417438 cites W936306301 @default.
• W2013417438 doi "https://doi.org/10.1097/00006534-200003000-00022" @default.
• W2013417438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10724258" @default.
• W2013417438 hasPublicationYear "2000" @default.
• W2013417438 type Work @default.
• W2013417438 sameAs 2013417438 @default.
• W2013417438 citedByCount "106" @default.
• W2013417438 countsByYear W20134174382012 @default.
• W2013417438 countsByYear W20134174382013 @default.
• W2013417438 countsByYear W20134174382014 @default.
• W2013417438 countsByYear W20134174382016 @default.
• W2013417438 countsByYear W20134174382017 @default.
• W2013417438 countsByYear W20134174382018 @default.
• W2013417438 countsByYear W20134174382019 @default.
• W2013417438 countsByYear W20134174382020 @default.
• W2013417438 countsByYear W20134174382022 @default.
• W2013417438 countsByYear W20134174382023 @default.
• W2013417438 crossrefType "journal-article" @default.
• W2013417438 hasAuthorship W2013417438A5004508233 @default.
• W2013417438 hasAuthorship W2013417438A5005728573 @default.
• W2013417438 hasAuthorship W2013417438A5042107654 @default.
• W2013417438 hasAuthorship W2013417438A5044556352 @default.
• W2013417438 hasAuthorship W2013417438A5046895879 @default.
• W2013417438 hasAuthorship W2013417438A5067965341 @default.
• W2013417438 hasAuthorship W2013417438A5081956660 @default.
• W2013417438 hasAuthorship W2013417438A5085080492 @default.
• W2013417438 hasConcept C104317684 @default.
• W2013417438 hasConcept C105702510 @default.
• W2013417438 hasConcept C109523444 @default.
• W2013417438 hasConcept C118131993 @default.
• W2013417438 hasConcept C126322002 @default.
• W2013417438 hasConcept C134018914 @default.
• W2013417438 hasConcept C142724271 @default.
• W2013417438 hasConcept C146539212 @default.
• W2013417438 hasConcept C189165786 @default.
• W2013417438 hasConcept C204787440 @default.
• W2013417438 hasConcept C2776164576 @default.
• W2013417438 hasConcept C2778229498 @default.
• W2013417438 hasConcept C2780024818 @default.
• W2013417438 hasConcept C2780550940 @default.
• W2013417438 hasConcept C2781013607 @default.
• W2013417438 hasConcept C2781218938 @default.
• W2013417438 hasConcept C2781403057 @default.
• W2013417438 hasConcept C3020332539 @default.
• W2013417438 hasConcept C31507581 @default.
• W2013417438 hasConcept C55493867 @default.
• W2013417438 hasConcept C71924100 @default.
• W2013417438 hasConcept C86803240 @default.
• W2013417438 hasConcept C95444343 @default.

• next