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- W2013424476 abstract "When administered by intraperitoneal injection daily for 3, 7 or 14 days, pargyline (75 mg/kg) significantly reduced rat hepatic microsomal ethylmorphine N-demethylase activity and cytochrome P-450 content. Injection of a lower dose of pargyline (15 mg/kg) failed to alter significantly either ethylmorphine N-demethylase activity or cytochrome P-450 content. Studies performed in vitro reveal that pargyline is metabolized to at least three compounds by rat hepatic microsomes. Thin-layer chromatography and other analyses suggest that one metabolite is an N-demethylated form, norpargyline." @default.
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- W2013424476 date "1978-01-01" @default.
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- W2013424476 title "Interaction of Pargyline with Rat Hepatic Microsomes" @default.
- W2013424476 doi "https://doi.org/10.1159/000136843" @default.
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