FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013428209> ?p ?o ?g. }

• W2013428209 endingPage "393" @default.
• W2013428209 startingPage "388" @default.
• W2013428209 abstract "<b><i>Background/Aims:</i></b> The objective of this study was to evaluate the efficacy of recombinant human growth hormone (rhGH) therapy and the influence of genotype on the response to rhGH therapy in children with Noonan syndrome (NS). <b><i>Methods:</i></b> 14 male and 4 female subjects with NS with short stature, whose height was <3rd percentile, were included. The rhGH was subcutaneously administered at a dose of 66 µg/kg/day. Mutations in the <i>PTPN11</i> gene were identified in 10 subjects (55.6%). Mutations in the <i>SOS1 </i>(2 children, 11.1%), <i>MEK1 </i>(1 child, 5.6%) and <i>KRAS</i> (1 child, 5.6%) genes were also found. <b><i>Results:</i></b> Height SDS increased from –2.8 ± 0.9 at the start of rhGH therapy to –2.0 ± 0.9 12 months later (p < 0.001). Height velocity increased from 5.0 ± 0.9 cm/year in the year before treatment to 8.9 ± 1.6 during treatment (p < 0.001). Changes in height SDS, height velocity, and serum IGF-1 level did not differ significantly between those children with or without <i>PTPN11</i> mutations. <b><i>Conclusion:</i></b> The rhGH therapy significantly improved the growth velocity and increased the serum IGF-1 level. Long-term correlation between genotype and rhGH therapy responsiveness needs to be addressed in a large population." @default.
• W2013428209 created "2016-06-24" @default.
• W2013428209 creator A5001889541 @default.
• W2013428209 creator A5006250732 @default.
• W2013428209 creator A5012117775 @default.
• W2013428209 creator A5014016038 @default.
• W2013428209 creator A5014622502 @default.
• W2013428209 creator A5016963864 @default.
• W2013428209 creator A5023047707 @default.
• W2013428209 creator A5029653138 @default.
• W2013428209 creator A5038190683 @default.
• W2013428209 creator A5044020391 @default.
• W2013428209 creator A5065250343 @default.
• W2013428209 date "2012-01-01" @default.
• W2013428209 modified "2023-09-26" @default.
• W2013428209 title "Response to Growth Hormone Therapy in Children with Noonan Syndrome: Correlation with or without <b><i>PTPN11</i></b> Gene Mutation" @default.
• W2013428209 cites W1488372279 @default.
• W2013428209 cites W1963564882 @default.
• W2013428209 cites W1967606132 @default.
• W2013428209 cites W1987413186 @default.
• W2013428209 cites W1990966255 @default.
• W2013428209 cites W2012645327 @default.
• W2013428209 cites W2018141684 @default.
• W2013428209 cites W2018958095 @default.
• W2013428209 cites W2023663427 @default.
• W2013428209 cites W2039980641 @default.
• W2013428209 cites W2062474259 @default.
• W2013428209 cites W2068672095 @default.
• W2013428209 cites W2068804834 @default.
• W2013428209 cites W2069765638 @default.
• W2013428209 cites W2078792788 @default.
• W2013428209 cites W2079805337 @default.
• W2013428209 cites W2081835814 @default.
• W2013428209 cites W2087867044 @default.
• W2013428209 cites W2097651100 @default.
• W2013428209 cites W2098174002 @default.
• W2013428209 cites W2099625528 @default.
• W2013428209 cites W2121195198 @default.
• W2013428209 cites W2129317874 @default.
• W2013428209 cites W2131109313 @default.
• W2013428209 cites W2140408745 @default.
• W2013428209 cites W2150611761 @default.
• W2013428209 cites W3121509427 @default.
• W2013428209 doi "https://doi.org/10.1159/000339677" @default.
• W2013428209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22777296" @default.
• W2013428209 hasPublicationYear "2012" @default.
• W2013428209 type Work @default.
• W2013428209 sameAs 2013428209 @default.
• W2013428209 citedByCount "26" @default.
• W2013428209 countsByYear W20134282092012 @default.
• W2013428209 countsByYear W20134282092014 @default.
• W2013428209 countsByYear W20134282092015 @default.
• W2013428209 countsByYear W20134282092016 @default.
• W2013428209 countsByYear W20134282092018 @default.
• W2013428209 countsByYear W20134282092019 @default.
• W2013428209 countsByYear W20134282092020 @default.
• W2013428209 countsByYear W20134282092021 @default.
• W2013428209 countsByYear W20134282092022 @default.
• W2013428209 countsByYear W20134282092023 @default.
• W2013428209 crossrefType "journal-article" @default.
• W2013428209 hasAuthorship W2013428209A5001889541 @default.
• W2013428209 hasAuthorship W2013428209A5006250732 @default.
• W2013428209 hasAuthorship W2013428209A5012117775 @default.
• W2013428209 hasAuthorship W2013428209A5014016038 @default.
• W2013428209 hasAuthorship W2013428209A5014622502 @default.
• W2013428209 hasAuthorship W2013428209A5016963864 @default.
• W2013428209 hasAuthorship W2013428209A5023047707 @default.
• W2013428209 hasAuthorship W2013428209A5029653138 @default.
• W2013428209 hasAuthorship W2013428209A5038190683 @default.
• W2013428209 hasAuthorship W2013428209A5044020391 @default.
• W2013428209 hasAuthorship W2013428209A5065250343 @default.
• W2013428209 hasBestOaLocation W20134282091 @default.
• W2013428209 hasConcept C121608353 @default.
• W2013428209 hasConcept C126322002 @default.
• W2013428209 hasConcept C134018914 @default.
• W2013428209 hasConcept C2776149932 @default.
• W2013428209 hasConcept C2777871287 @default.
• W2013428209 hasConcept C2781187634 @default.
• W2013428209 hasConcept C31734879 @default.
• W2013428209 hasConcept C526805850 @default.
• W2013428209 hasConcept C71924100 @default.
• W2013428209 hasConcept C89551170 @default.
• W2013428209 hasConceptScore W2013428209C121608353 @default.
• W2013428209 hasConceptScore W2013428209C126322002 @default.
• W2013428209 hasConceptScore W2013428209C134018914 @default.
• W2013428209 hasConceptScore W2013428209C2776149932 @default.
• W2013428209 hasConceptScore W2013428209C2777871287 @default.
• W2013428209 hasConceptScore W2013428209C2781187634 @default.
• W2013428209 hasConceptScore W2013428209C31734879 @default.
• W2013428209 hasConceptScore W2013428209C526805850 @default.
• W2013428209 hasConceptScore W2013428209C71924100 @default.
• W2013428209 hasConceptScore W2013428209C89551170 @default.
• W2013428209 hasIssue "6" @default.
• W2013428209 hasLocation W20134282091 @default.
• W2013428209 hasLocation W20134282092 @default.
• W2013428209 hasOpenAccess W2013428209 @default.
• W2013428209 hasPrimaryLocation W20134282091 @default.
• W2013428209 hasRelatedWork W1964063643 @default.

• next