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• W2013436544 abstract "Neuronal nicotinic acetylcholine receptors (nAChRs) are implicated in the reinforcing effects of many drugs of abuse, including ethanol. The present study examined the efficacy of cytisine, a nAChR partial agonist, and lobeline, a putative nAChR antagonist, on the maintenance of ethanol drinking by HAD-2 rats. Adult male HAD-2 rats were given access to ethanol (15 and 30%, with ad libitum access to water and food) 22 h/day for 12 weeks, beginning at 60 days of age, after which cytisine (0.0, 0.5, and 1.5 mg/kg) was tested for 3 consecutive days. The rats were given an 18-day washout period and were then tested with lobeline (0.0, 1.0, and 5.0 mg/kg) for 3 consecutive days. Ethanol intake was measured at 1, 4, and 22 h postinjection. Rats were injected intraperitoneally just before lights out (1200 h). There was a significant main effect of cytisine treatment on the second test day, with the 1.5 mg/kg dose significantly reducing ethanol intake at the 1- and 4-h time-points, relative to saline, and the 0.5 mg/kg dose inducing a significant reduction at the 4-h time-point. Conversely, lobeline treatment resulted in significant main effects of treatment for all three time-points within each test day, with the 5.0 mg/kg dose significantly reducing ethanol intake, relative to saline, at each time-point within each test day. These findings provide further evidence that activity at the nAChR influences ethanol intake and is a promising target for pharmacotherapy development for the treatment of alcohol dependence and relapse." @default.
• W2013436544 created "2016-06-24" @default.
• W2013436544 creator A5015376742 @default.
• W2013436544 creator A5065579684 @default.
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• W2013436544 date "2009-12-01" @default.
• W2013436544 modified "2023-10-16" @default.
• W2013436544 title "Nicotinic receptor ligands reduce ethanol intake by high alcohol–drinking HAD-2 rats" @default.
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• W2013436544 doi "https://doi.org/10.1016/j.alcohol.2009.09.027" @default.
• W2013436544 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2813038" @default.
• W2013436544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20004336" @default.
• W2013436544 hasPublicationYear "2009" @default.
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