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- W2013446830 endingPage "380" @default.
- W2013446830 startingPage "373" @default.
- W2013446830 abstract "Misfolding diseases are a wide group of devastating disorders characterized by the accumulation of pathological protein aggregates. Although these disorders still lack an effective treatment, new antibody-based strategies are emerging and entering clinical trials. The intrabody approach is a gene-based technology developed to neutralize or modify the function of intracellular and extracellular target antigens. Because intrabodies can potentially target all the different isoforms of a misfolding-prone protein, including pathological conformations, they are emerging as therapeutic molecules for the treatment of misfolding diseases, including Alzheimer's, Parkinson's, Huntington's and prion diseases. This review will provide a description of the intrabody approach, an update of preclinical studies on misfolding diseases and an outlook on the intrabody delivery issue for therapeutic purposes." @default.
- W2013446830 created "2016-06-24" @default.
- W2013446830 creator A5045302192 @default.
- W2013446830 creator A5073180216 @default.
- W2013446830 date "2008-09-01" @default.
- W2013446830 modified "2023-10-18" @default.
- W2013446830 title "The potential of intracellular antibodies for therapeutic targeting of protein-misfolding diseases" @default.
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- W2013446830 doi "https://doi.org/10.1016/j.molmed.2008.07.004" @default.
- W2013446830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18693139" @default.
- W2013446830 hasPublicationYear "2008" @default.
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