FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013450122> ?p ?o ?g. }

• W2013450122 endingPage "e33482" @default.
• W2013450122 startingPage "e33482" @default.
• W2013450122 abstract "Saccharomyces cerevisiae mitochondrial DNA polymerase (Mip1) contains a C-terminal extension (CTE) of 279 amino acid residues. The CTE is required for mitochondrial DNA maintenance in yeast but is absent in higher eukaryotes. Here we use recombinant Mip1 C-terminal deletion mutants to investigate functional importance of the CTE. We show that partial removal of the CTE in Mip1Δ216 results in strong preference for exonucleolytic degradation rather than DNA polymerization. This disbalance in exonuclease and polymerase activities is prominent at suboptimal dNTP concentrations and in the absence of correctly pairing nucleotide. Mip1Δ216 also displays reduced ability to synthesize DNA through double-stranded regions. Full removal of the CTE in Mip1Δ279 results in complete loss of Mip1 polymerase activity, however the mutant retains its exonuclease activity. These results allow us to propose that CTE functions as a part of Mip1 polymerase domain that stabilizes the substrate primer end at the polymerase active site, and is therefore required for efficient mitochondrial DNA replication in vivo." @default.
• W2013450122 created "2016-06-24" @default.
• W2013450122 creator A5023233242 @default.
• W2013450122 creator A5035489993 @default.
• W2013450122 creator A5079725235 @default.
• W2013450122 creator A5085043075 @default.
• W2013450122 date "2012-03-14" @default.
• W2013450122 modified "2023-10-02" @default.
• W2013450122 title "C-Terminal Extension of the Yeast Mitochondrial DNA Polymerase Determines the Balance between Synthesis and Degradation" @default.
• W2013450122 cites W1493605791 @default.
• W2013450122 cites W1535907462 @default.
• W2013450122 cites W1575228817 @default.
• W2013450122 cites W1793843239 @default.
• W2013450122 cites W1965582223 @default.
• W2013450122 cites W1966681259 @default.
• W2013450122 cites W1971681144 @default.
• W2013450122 cites W1974585689 @default.
• W2013450122 cites W1985921871 @default.
• W2013450122 cites W1986113777 @default.
• W2013450122 cites W1987305037 @default.
• W2013450122 cites W1994131907 @default.
• W2013450122 cites W2001256046 @default.
• W2013450122 cites W2001294987 @default.
• W2013450122 cites W2001573278 @default.
• W2013450122 cites W2004936589 @default.
• W2013450122 cites W2006474795 @default.
• W2013450122 cites W2015535976 @default.
• W2013450122 cites W2038833748 @default.
• W2013450122 cites W2045199120 @default.
• W2013450122 cites W2053244885 @default.
• W2013450122 cites W2059453827 @default.
• W2013450122 cites W2069511958 @default.
• W2013450122 cites W2071728424 @default.
• W2013450122 cites W2072916700 @default.
• W2013450122 cites W2076210586 @default.
• W2013450122 cites W2079964539 @default.
• W2013450122 cites W2089157935 @default.
• W2013450122 cites W2092998957 @default.
• W2013450122 cites W2104017463 @default.
• W2013450122 cites W2111497781 @default.
• W2013450122 cites W2115781467 @default.
• W2013450122 cites W2116197652 @default.
• W2013450122 cites W2128968369 @default.
• W2013450122 cites W2135130725 @default.
• W2013450122 cites W2141231332 @default.
• W2013450122 cites W2145220051 @default.
• W2013450122 cites W2151667123 @default.
• W2013450122 cites W2164318810 @default.
• W2013450122 cites W2167537912 @default.
• W2013450122 cites W2171557432 @default.
• W2013450122 cites W2922395101 @default.
• W2013450122 doi "https://doi.org/10.1371/journal.pone.0033482" @default.
• W2013450122 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3303844" @default.
• W2013450122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22432028" @default.
• W2013450122 hasPublicationYear "2012" @default.
• W2013450122 type Work @default.
• W2013450122 sameAs 2013450122 @default.
• W2013450122 citedByCount "12" @default.
• W2013450122 countsByYear W20134501222013 @default.
• W2013450122 countsByYear W20134501222015 @default.
• W2013450122 countsByYear W20134501222019 @default.
• W2013450122 countsByYear W20134501222020 @default.
• W2013450122 countsByYear W20134501222021 @default.
• W2013450122 countsByYear W20134501222023 @default.
• W2013450122 crossrefType "journal-article" @default.
• W2013450122 hasAuthorship W2013450122A5023233242 @default.
• W2013450122 hasAuthorship W2013450122A5035489993 @default.
• W2013450122 hasAuthorship W2013450122A5079725235 @default.
• W2013450122 hasAuthorship W2013450122A5085043075 @default.
• W2013450122 hasBestOaLocation W20134501221 @default.
• W2013450122 hasConcept C104317684 @default.
• W2013450122 hasConcept C153911025 @default.
• W2013450122 hasConcept C156719811 @default.
• W2013450122 hasConcept C164965036 @default.
• W2013450122 hasConcept C178790620 @default.
• W2013450122 hasConcept C185592680 @default.
• W2013450122 hasConcept C24586158 @default.
• W2013450122 hasConcept C2756471 @default.
• W2013450122 hasConcept C2777501222 @default.
• W2013450122 hasConcept C2777563447 @default.
• W2013450122 hasConcept C31254050 @default.
• W2013450122 hasConcept C49105822 @default.
• W2013450122 hasConcept C54415193 @default.
• W2013450122 hasConcept C552990157 @default.
• W2013450122 hasConcept C55493867 @default.
• W2013450122 hasConcept C73573662 @default.
• W2013450122 hasConcept C82381507 @default.
• W2013450122 hasConcept C86803240 @default.
• W2013450122 hasConcept C88354546 @default.
• W2013450122 hasConcept C95444343 @default.
• W2013450122 hasConceptScore W2013450122C104317684 @default.
• W2013450122 hasConceptScore W2013450122C153911025 @default.
• W2013450122 hasConceptScore W2013450122C156719811 @default.
• W2013450122 hasConceptScore W2013450122C164965036 @default.
• W2013450122 hasConceptScore W2013450122C178790620 @default.
• W2013450122 hasConceptScore W2013450122C185592680 @default.
• W2013450122 hasConceptScore W2013450122C24586158 @default.
• W2013450122 hasConceptScore W2013450122C2756471 @default.

• next