FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013454038> ?p ?o ?g. }

• W2013454038 endingPage "2336" @default.
• W2013454038 startingPage "2324" @default.
• W2013454038 abstract "Abstract 1,1-Bis(3′-indolyl)-1-(p-t-butylphenyl)methane (DIM-C-pPhtBu) is a peroxisome proliferator–activated receptor γ (PPARγ) agonist, and treatment of SKOV3 ovarian cancer cells with this compound (5 μmol/L) inhibits cell proliferation, whereas up to 15 μmol/L rosiglitazone had no effect on cell growth. DIM-C-pPhtBu also inhibits G0-G1 to S phase cell cycle progression and this is linked, in part, to PPARγ-dependent induction of the cyclin-dependent kinase inhibitor p21. DIM-C-pPhtBu induces PPARγ-independent down-regulation of cyclin D1 and we therefore further investigated activation of receptor-independent pathways. DIM-C-pPhtBu also induced apoptosis in SKOV3 cells and this was related to induction of glucose-related protein 78, which is typically up-regulated as part of the unfolded protein response during endoplasmic reticulum (ER) stress. Activation of ER stress was also observed in other ovarian cancer cell lines treated with DIM-C-pPhtBu. In addition, DIM-C-pPhtBu induced CCAAT/enhancer binding protein homologous protein through both ER stress and c-jun NH2-terminal kinase–dependent pathways, and CCAAT/enhancer binding protein homologous protein activated death receptor 5 and the extrinsic pathway of apoptosis. These results show that DIM-C-pPhtBu inhibits growth and induces apoptosis in ovarian cancer cells through both PPARγ-dependent and PPARγ-independent pathways, and this complex mechanism of action will be advantageous for future clinical development of these compounds for treatment of ovarian cancer. [Mol Cancer Ther 2006;5(9):2324–38]" @default.
• W2013454038 created "2016-06-24" @default.
• W2013454038 creator A5012026287 @default.
• W2013454038 creator A5036575223 @default.
• W2013454038 creator A5088223962 @default.
• W2013454038 date "2006-09-01" @default.
• W2013454038 modified "2023-10-13" @default.
• W2013454038 title "1,1-Bis(3′-indolyl)-1-(<i>p</i>-substituted phenyl)methanes inhibit ovarian cancer cell growth through peroxisome proliferator–activated receptor–dependent and independent pathways" @default.
• W2013454038 cites W1750631750 @default.
• W2013454038 cites W1951826532 @default.
• W2013454038 cites W1965727325 @default.
• W2013454038 cites W1967816930 @default.
• W2013454038 cites W1972749413 @default.
• W2013454038 cites W1973839408 @default.
• W2013454038 cites W1974671082 @default.
• W2013454038 cites W1975293170 @default.
• W2013454038 cites W1979069886 @default.
• W2013454038 cites W1984893022 @default.
• W2013454038 cites W1988629619 @default.
• W2013454038 cites W1990529844 @default.
• W2013454038 cites W1995975692 @default.
• W2013454038 cites W1997388541 @default.
• W2013454038 cites W1999513011 @default.
• W2013454038 cites W2014182737 @default.
• W2013454038 cites W2017111227 @default.
• W2013454038 cites W2020013080 @default.
• W2013454038 cites W2022048961 @default.
• W2013454038 cites W2024823380 @default.
• W2013454038 cites W2025210272 @default.
• W2013454038 cites W2026386836 @default.
• W2013454038 cites W2028513543 @default.
• W2013454038 cites W2029964395 @default.
• W2013454038 cites W2030093162 @default.
• W2013454038 cites W2054438783 @default.
• W2013454038 cites W2057433500 @default.
• W2013454038 cites W2059912335 @default.
• W2013454038 cites W2071669935 @default.
• W2013454038 cites W2077948125 @default.
• W2013454038 cites W2088144835 @default.
• W2013454038 cites W2088605481 @default.
• W2013454038 cites W2091321756 @default.
• W2013454038 cites W2099683650 @default.
• W2013454038 cites W2099939845 @default.
• W2013454038 cites W2105078414 @default.
• W2013454038 cites W2109465247 @default.
• W2013454038 cites W2113235032 @default.
• W2013454038 cites W2115311570 @default.
• W2013454038 cites W2117078917 @default.
• W2013454038 cites W2122368744 @default.
• W2013454038 cites W2127629026 @default.
• W2013454038 cites W2128348076 @default.
• W2013454038 cites W2133862322 @default.
• W2013454038 cites W2145168681 @default.
• W2013454038 cites W2146720128 @default.
• W2013454038 cites W2158609897 @default.
• W2013454038 cites W2160341684 @default.
• W2013454038 cites W2170169143 @default.
• W2013454038 cites W2172256092 @default.
• W2013454038 cites W4293202361 @default.
• W2013454038 cites W4297754410 @default.
• W2013454038 doi "https://doi.org/10.1158/1535-7163.mct-06-0184" @default.
• W2013454038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16985067" @default.
• W2013454038 hasPublicationYear "2006" @default.
• W2013454038 type Work @default.
• W2013454038 sameAs 2013454038 @default.
• W2013454038 citedByCount "33" @default.
• W2013454038 countsByYear W20134540382012 @default.
• W2013454038 countsByYear W20134540382013 @default.
• W2013454038 countsByYear W20134540382014 @default.
• W2013454038 countsByYear W20134540382015 @default.
• W2013454038 countsByYear W20134540382020 @default.
• W2013454038 countsByYear W20134540382021 @default.
• W2013454038 countsByYear W20134540382022 @default.
• W2013454038 crossrefType "journal-article" @default.
• W2013454038 hasAuthorship W2013454038A5012026287 @default.
• W2013454038 hasAuthorship W2013454038A5036575223 @default.
• W2013454038 hasAuthorship W2013454038A5088223962 @default.
• W2013454038 hasBestOaLocation W20134540381 @default.
• W2013454038 hasConcept C139447449 @default.
• W2013454038 hasConcept C153911025 @default.
• W2013454038 hasConcept C158617107 @default.
• W2013454038 hasConcept C170493617 @default.
• W2013454038 hasConcept C184235292 @default.
• W2013454038 hasConcept C185592680 @default.
• W2013454038 hasConcept C187345961 @default.
• W2013454038 hasConcept C190283241 @default.
• W2013454038 hasConcept C199835354 @default.
• W2013454038 hasConcept C29537977 @default.
• W2013454038 hasConcept C502942594 @default.
• W2013454038 hasConcept C55493867 @default.
• W2013454038 hasConcept C62112901 @default.
• W2013454038 hasConcept C62478195 @default.
• W2013454038 hasConcept C86803240 @default.
• W2013454038 hasConcept C95444343 @default.
• W2013454038 hasConcept C97029542 @default.
• W2013454038 hasConceptScore W2013454038C139447449 @default.
• W2013454038 hasConceptScore W2013454038C153911025 @default.
• W2013454038 hasConceptScore W2013454038C158617107 @default.

• next