FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013455135> ?p ?o ?g. }

• W2013455135 endingPage "55" @default.
• W2013455135 startingPage "48" @default.
• W2013455135 abstract "The binding interactions of 22 flavonoids (9 aglycones and 13 glycosides) with DNA triplexes were investigated using electrospray ionization mass spectrometry (ESI-MS). The results revealed that the hydroxyl positions of aglycones, the locations and numbers of saccharide, as well as the aglycone skeletons play roles in the triplex-binding properties of flavonoids. The presence of 3-OH, or 3′-OH, or replacement of 4′-OH with methoxy group in aglycones decreased the fraction of bound DNA sharply. Flavonoid glycosides exhibit higher binding affinities towards the DNA triplexes than their aglycone counterparts. Glycosylations of flavones at the 8-C position and isoflavones at the 7-O position show higher binding affinities than those on the other positions of ring A of aglycones. Glycosylation with a disaccharide on C3 position of flavonol results in higher binding affinity than that with monosaccharide. Flexibility of the ring B is favorable for its interaction with DNA triplex. According to sustained off-resonance irradiation collision-induced dissociation (SORI-CID) experiments, glycosylation and non-planarity of flavonoid aglycones lead to different dissociation pathways of the flavonoid/triplex complexes. The differences between dissociation patterns suggest different DNA-binding modes or DNA-binding affinities. Although the exact binding geometry of the flavonoid–triplex complexes cannot be specified, the results may be helpful for understanding the triplex-binding properties of flavonoids and give a clue to design of triplex-binding ligands." @default.
• W2013455135 created "2016-06-24" @default.
• W2013455135 creator A5000894548 @default.
• W2013455135 creator A5008391277 @default.
• W2013455135 creator A5013463034 @default.
• W2013455135 creator A5057688068 @default.
• W2013455135 creator A5060341807 @default.
• W2013455135 date "2009-06-01" @default.
• W2013455135 modified "2023-09-26" @default.
• W2013455135 title "A study of the non-covalent interaction between flavonoids and DNA triplexes by electrospray ionization mass spectrometry" @default.
• W2013455135 cites W1578022505 @default.
• W2013455135 cites W1966930122 @default.
• W2013455135 cites W1967936457 @default.
• W2013455135 cites W1970629661 @default.
• W2013455135 cites W1977166331 @default.
• W2013455135 cites W1984934469 @default.
• W2013455135 cites W1985229938 @default.
• W2013455135 cites W1987139320 @default.
• W2013455135 cites W1999364887 @default.
• W2013455135 cites W2009151773 @default.
• W2013455135 cites W2013029823 @default.
• W2013455135 cites W2020906531 @default.
• W2013455135 cites W2021842569 @default.
• W2013455135 cites W2023709877 @default.
• W2013455135 cites W2024720794 @default.
• W2013455135 cites W2026380372 @default.
• W2013455135 cites W2035152060 @default.
• W2013455135 cites W2035925517 @default.
• W2013455135 cites W2036369827 @default.
• W2013455135 cites W2037130841 @default.
• W2013455135 cites W2038834495 @default.
• W2013455135 cites W2041175802 @default.
• W2013455135 cites W2048695976 @default.
• W2013455135 cites W2049576341 @default.
• W2013455135 cites W2051915261 @default.
• W2013455135 cites W2060502007 @default.
• W2013455135 cites W2061474126 @default.
• W2013455135 cites W2063100012 @default.
• W2013455135 cites W2063687642 @default.
• W2013455135 cites W2067857616 @default.
• W2013455135 cites W2068897888 @default.
• W2013455135 cites W2070455847 @default.
• W2013455135 cites W2076533513 @default.
• W2013455135 cites W2077170752 @default.
• W2013455135 cites W2077429821 @default.
• W2013455135 cites W2081222587 @default.
• W2013455135 cites W2088219233 @default.
• W2013455135 cites W2090113459 @default.
• W2013455135 cites W2092145209 @default.
• W2013455135 cites W2093286842 @default.
• W2013455135 cites W2094761209 @default.
• W2013455135 cites W2101295639 @default.
• W2013455135 cites W2114348015 @default.
• W2013455135 cites W2123017921 @default.
• W2013455135 cites W2134979720 @default.
• W2013455135 cites W2135536617 @default.
• W2013455135 cites W2146920726 @default.
• W2013455135 cites W2149966580 @default.
• W2013455135 cites W2158390129 @default.
• W2013455135 cites W2160515172 @default.
• W2013455135 cites W2162331245 @default.
• W2013455135 cites W2409407580 @default.
• W2013455135 doi "https://doi.org/10.1016/j.ijms.2009.01.007" @default.
• W2013455135 hasPublicationYear "2009" @default.
• W2013455135 type Work @default.
• W2013455135 sameAs 2013455135 @default.
• W2013455135 citedByCount "26" @default.
• W2013455135 countsByYear W20134551352012 @default.
• W2013455135 countsByYear W20134551352013 @default.
• W2013455135 countsByYear W20134551352014 @default.
• W2013455135 countsByYear W20134551352015 @default.
• W2013455135 countsByYear W20134551352016 @default.
• W2013455135 countsByYear W20134551352017 @default.
• W2013455135 countsByYear W20134551352018 @default.
• W2013455135 countsByYear W20134551352019 @default.
• W2013455135 countsByYear W20134551352021 @default.
• W2013455135 countsByYear W20134551352022 @default.
• W2013455135 countsByYear W20134551352023 @default.
• W2013455135 crossrefType "journal-article" @default.
• W2013455135 hasAuthorship W2013455135A5000894548 @default.
• W2013455135 hasAuthorship W2013455135A5008391277 @default.
• W2013455135 hasAuthorship W2013455135A5013463034 @default.
• W2013455135 hasAuthorship W2013455135A5057688068 @default.
• W2013455135 hasAuthorship W2013455135A5060341807 @default.
• W2013455135 hasConcept C162356407 @default.
• W2013455135 hasConcept C185592680 @default.
• W2013455135 hasConcept C194671627 @default.
• W2013455135 hasConcept C2778004101 @default.
• W2013455135 hasConcept C2779054382 @default.
• W2013455135 hasConcept C2779396346 @default.
• W2013455135 hasConcept C40684141 @default.
• W2013455135 hasConcept C43617362 @default.
• W2013455135 hasConcept C552990157 @default.
• W2013455135 hasConcept C55493867 @default.
• W2013455135 hasConcept C71240020 @default.
• W2013455135 hasConceptScore W2013455135C162356407 @default.
• W2013455135 hasConceptScore W2013455135C185592680 @default.
• W2013455135 hasConceptScore W2013455135C194671627 @default.

• next