Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013455786> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2013455786 endingPage "6008" @default.
- W2013455786 startingPage "6003" @default.
- W2013455786 abstract "The Ah locus in the C57BL/6N mouse regulates at least two cytochrome P-450 gene products, termed in the mouse P1-450 and P3-450; these two enzymes are so named because each is responsible for the highest turnover number for the substrates benzo[a]pyrene and acetanilide, respectively. A cDNA library was prepared in pBR322 from sucrose gradient fractionated total liver poly(A+)-enriched RNA (approximately 20 S) from 2,3,7,8-tetrachlorodibenzo-p-dioxin- (TCDD) treated C57BL/6N (Ahb/Ahb) mice. Differential colony hybridization screening, with [32P]cDNA probes derived from total liver mRNA of both TCDD-treated and control C57BL/6N mice, yielded pP(3)450-21 (1710 base pair) and pP(1)450-57 (1770 base pair) cDNA clones. pP(1)450-57 was found to have 690 base pairs 5'-ward of the original P1-450 cDNA cloned in this laboratory. Restriction maps of pP(3)450-21 and pP(1)450-57 are markedly different and clearly are derived from separate genes. By means of hybridization-translation-arrest experiments, anti-(P3-450) precipitates the translation product (Mr approximately equal to 55000) of mRNA specifically hybridizing to pP(3)450-21. It is also shown that hybridization-translation-arrest experiments using polyclonal antibodies are not specific for proof of a P-450 cDNA clone. pP(3)450-21 was used to probe liver mRNA from Ahb/Ahb, Ahb/Ahd, and Ahd/Ahd mice treated with 3-methylcholanthrene, beta-naphthoflavone, aroclor 1254, isosafrole, low TCDD, or high TCDD. These genetic data rigorously demonstrate control of the P3-450 (20S) mRNA induction process by the Ah receptor. pP(3)450-21 fragments hybridized to TCDD-induced C57BL/6N mRNA and to a portion of the cloned 5' end of the P1-450 gene from a mouse MOPC 41 plasmacytoma library.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2013455786 created "2016-06-24" @default.
- W2013455786 creator A5029237881 @default.
- W2013455786 creator A5029336335 @default.
- W2013455786 date "1984-12-01" @default.
- W2013455786 modified "2023-09-26" @default.
- W2013455786 title "Regulation of mouse cytochrome P3-450 by the Ah receptor. Studies with a P3-450 cDNA clone" @default.
- W2013455786 cites W1480003911 @default.
- W2013455786 cites W1490925667 @default.
- W2013455786 cites W1496489701 @default.
- W2013455786 cites W1499517824 @default.
- W2013455786 cites W1508613684 @default.
- W2013455786 cites W1512776128 @default.
- W2013455786 cites W1558770975 @default.
- W2013455786 cites W1563025751 @default.
- W2013455786 cites W1565806333 @default.
- W2013455786 cites W1566763721 @default.
- W2013455786 cites W1570768358 @default.
- W2013455786 cites W1570782502 @default.
- W2013455786 cites W1577296862 @default.
- W2013455786 cites W158373933 @default.
- W2013455786 cites W1600537635 @default.
- W2013455786 cites W1795036143 @default.
- W2013455786 cites W1967072617 @default.
- W2013455786 cites W1971027234 @default.
- W2013455786 cites W1977501093 @default.
- W2013455786 cites W1991112068 @default.
- W2013455786 cites W1995932704 @default.
- W2013455786 cites W1998342457 @default.
- W2013455786 cites W2001471445 @default.
- W2013455786 cites W2001918644 @default.
- W2013455786 cites W2002719254 @default.
- W2013455786 cites W2004535441 @default.
- W2013455786 cites W2016613744 @default.
- W2013455786 cites W2022915138 @default.
- W2013455786 cites W2038305047 @default.
- W2013455786 cites W2040276985 @default.
- W2013455786 cites W2045851121 @default.
- W2013455786 cites W2057478837 @default.
- W2013455786 cites W2063432708 @default.
- W2013455786 cites W2063450941 @default.
- W2013455786 cites W2066160869 @default.
- W2013455786 cites W2243583720 @default.
- W2013455786 cites W233730272 @default.
- W2013455786 cites W2342230255 @default.
- W2013455786 cites W2420483227 @default.
- W2013455786 cites W2478918056 @default.
- W2013455786 cites W2585669458 @default.
- W2013455786 doi "https://doi.org/10.1021/bi00320a016" @default.
- W2013455786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6395889" @default.
- W2013455786 hasPublicationYear "1984" @default.
- W2013455786 type Work @default.
- W2013455786 sameAs 2013455786 @default.
- W2013455786 citedByCount "53" @default.
- W2013455786 countsByYear W20134557862016 @default.
- W2013455786 crossrefType "journal-article" @default.
- W2013455786 hasAuthorship W2013455786A5029237881 @default.
- W2013455786 hasAuthorship W2013455786A5029336335 @default.
- W2013455786 hasConcept C104317684 @default.
- W2013455786 hasConcept C105580179 @default.
- W2013455786 hasConcept C153911025 @default.
- W2013455786 hasConcept C181199279 @default.
- W2013455786 hasConcept C185592680 @default.
- W2013455786 hasConcept C187882448 @default.
- W2013455786 hasConcept C189482833 @default.
- W2013455786 hasConcept C2780768313 @default.
- W2013455786 hasConcept C55493867 @default.
- W2013455786 hasConcept C86803240 @default.
- W2013455786 hasConceptScore W2013455786C104317684 @default.
- W2013455786 hasConceptScore W2013455786C105580179 @default.
- W2013455786 hasConceptScore W2013455786C153911025 @default.
- W2013455786 hasConceptScore W2013455786C181199279 @default.
- W2013455786 hasConceptScore W2013455786C185592680 @default.
- W2013455786 hasConceptScore W2013455786C187882448 @default.
- W2013455786 hasConceptScore W2013455786C189482833 @default.
- W2013455786 hasConceptScore W2013455786C2780768313 @default.
- W2013455786 hasConceptScore W2013455786C55493867 @default.
- W2013455786 hasConceptScore W2013455786C86803240 @default.
- W2013455786 hasIssue "25" @default.
- W2013455786 hasLocation W20134557861 @default.
- W2013455786 hasLocation W20134557862 @default.
- W2013455786 hasOpenAccess W2013455786 @default.
- W2013455786 hasPrimaryLocation W20134557861 @default.
- W2013455786 hasRelatedWork W1966427723 @default.
- W2013455786 hasRelatedWork W1982498290 @default.
- W2013455786 hasRelatedWork W2031687390 @default.
- W2013455786 hasRelatedWork W2035178353 @default.
- W2013455786 hasRelatedWork W2060783010 @default.
- W2013455786 hasRelatedWork W2067544802 @default.
- W2013455786 hasRelatedWork W2078899906 @default.
- W2013455786 hasRelatedWork W2092621937 @default.
- W2013455786 hasRelatedWork W2093183948 @default.
- W2013455786 hasRelatedWork W2413242955 @default.
- W2013455786 hasVolume "23" @default.
- W2013455786 isParatext "false" @default.
- W2013455786 isRetracted "false" @default.
- W2013455786 magId "2013455786" @default.
- W2013455786 workType "article" @default.