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- W2013456890 abstract "The ADP,ATP carrier of rat liver mitochondria is specifically inhibited by Meisenheimer-type trinitrophenyl (TNP) derivatives of ADP and ATP. Due to a systematic inhibition study we could show that the TNP-moiety itself, even in the 2', 3'-O-cyclic Meisenheimer complex, revealed no inhibition of mitochondrial ADP,ATP transport. Nucleosidic TNP-compounds are weak inhibitors. Introduction of a phosphate group at the 5'-position, however, enhances the inhibitory power markedly. Our findings point to a synergistic effect of the 5'-phosphate chain and the TNP-moiety. Irreversible inhibition by TNP-nucleotides can be ruled out to the fact that the inhibited ADP,ATP-transport system is fully reactivated by addition of albumin." @default.
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- W2013456890 date "1983-05-02" @default.
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- W2013456890 title "Inhibition study of ADP,ATP transport in mitochondria with trinitrophenyl-modified substrates" @default.
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- W2013456890 doi "https://doi.org/10.1016/0014-5793(83)80197-5" @default.
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