Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013457041> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2013457041 abstract "Doridosine, an adenosine analogue, causes, in vivo, hypotension, reduction of heart rates, muscle relaxation and anti-inflammatory effects through adenosine A1 and A2 receptors. A series of doridosine derivatives was synthesized in a search for compounds with more selective adenosine A1 receptor activity. These derivatives were characterized for binding to the respective adenosine receptors and for their cardiovascular effects. We used competition binding studies with highly selective radioligands: [3H]cyclohexyladenosine for adenosine A1 and [3H]CGS 21680 for adenosine A2 binding assays. The results for eight doridosine derivatives revealed that 1-cyclopropylisoguanosine (BN-063) and 1-allylisoguanosine (AZ-108-1) were more selective for the adenosine A1 receptor. In vivo, both BN-063 and AZ-108-1 caused significant bradycardia but no obvious effect on blood pressure. The bradycardia was almost completely blocked by 1,3-dipropyl-8-cyclopentylxanthine (DPCPX, a specific adenosine A1 receptor antagonist)." @default.
- W2013457041 created "2016-06-24" @default.
- W2013457041 creator A5002032472 @default.
- W2013457041 creator A5013661718 @default.
- W2013457041 creator A5056021819 @default.
- W2013457041 creator A5059625451 @default.
- W2013457041 date "1993-10-01" @default.
- W2013457041 modified "2023-09-28" @default.
- W2013457041 title "Doridosine derivatives: binding at adenosine receptors and in vivo effects" @default.
- W2013457041 cites W1495845054 @default.
- W2013457041 cites W1533354213 @default.
- W2013457041 cites W1963941498 @default.
- W2013457041 cites W1969266962 @default.
- W2013457041 cites W1982590490 @default.
- W2013457041 cites W1987516351 @default.
- W2013457041 cites W2017020033 @default.
- W2013457041 cites W2024554893 @default.
- W2013457041 cites W2043813981 @default.
- W2013457041 cites W2124451760 @default.
- W2013457041 cites W2133823766 @default.
- W2013457041 cites W2425133456 @default.
- W2013457041 cites W2949484188 @default.
- W2013457041 doi "https://doi.org/10.1016/0014-2999(93)90372-o" @default.
- W2013457041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8276062" @default.
- W2013457041 hasPublicationYear "1993" @default.
- W2013457041 type Work @default.
- W2013457041 sameAs 2013457041 @default.
- W2013457041 citedByCount "10" @default.
- W2013457041 countsByYear W20134570412014 @default.
- W2013457041 countsByYear W20134570412018 @default.
- W2013457041 crossrefType "journal-article" @default.
- W2013457041 hasAuthorship W2013457041A5002032472 @default.
- W2013457041 hasAuthorship W2013457041A5013661718 @default.
- W2013457041 hasAuthorship W2013457041A5056021819 @default.
- W2013457041 hasAuthorship W2013457041A5059625451 @default.
- W2013457041 hasConcept C126322002 @default.
- W2013457041 hasConcept C134018914 @default.
- W2013457041 hasConcept C150903083 @default.
- W2013457041 hasConcept C158424129 @default.
- W2013457041 hasConcept C170493617 @default.
- W2013457041 hasConcept C172590197 @default.
- W2013457041 hasConcept C182683403 @default.
- W2013457041 hasConcept C185592680 @default.
- W2013457041 hasConcept C207001950 @default.
- W2013457041 hasConcept C2776885963 @default.
- W2013457041 hasConcept C2776991684 @default.
- W2013457041 hasConcept C2778938600 @default.
- W2013457041 hasConcept C2780231331 @default.
- W2013457041 hasConcept C55493867 @default.
- W2013457041 hasConcept C67907053 @default.
- W2013457041 hasConcept C71924100 @default.
- W2013457041 hasConcept C86803240 @default.
- W2013457041 hasConcept C98274493 @default.
- W2013457041 hasConceptScore W2013457041C126322002 @default.
- W2013457041 hasConceptScore W2013457041C134018914 @default.
- W2013457041 hasConceptScore W2013457041C150903083 @default.
- W2013457041 hasConceptScore W2013457041C158424129 @default.
- W2013457041 hasConceptScore W2013457041C170493617 @default.
- W2013457041 hasConceptScore W2013457041C172590197 @default.
- W2013457041 hasConceptScore W2013457041C182683403 @default.
- W2013457041 hasConceptScore W2013457041C185592680 @default.
- W2013457041 hasConceptScore W2013457041C207001950 @default.
- W2013457041 hasConceptScore W2013457041C2776885963 @default.
- W2013457041 hasConceptScore W2013457041C2776991684 @default.
- W2013457041 hasConceptScore W2013457041C2778938600 @default.
- W2013457041 hasConceptScore W2013457041C2780231331 @default.
- W2013457041 hasConceptScore W2013457041C55493867 @default.
- W2013457041 hasConceptScore W2013457041C67907053 @default.
- W2013457041 hasConceptScore W2013457041C71924100 @default.
- W2013457041 hasConceptScore W2013457041C86803240 @default.
- W2013457041 hasConceptScore W2013457041C98274493 @default.
- W2013457041 hasLocation W20134570411 @default.
- W2013457041 hasLocation W20134570412 @default.
- W2013457041 hasOpenAccess W2013457041 @default.
- W2013457041 hasPrimaryLocation W20134570411 @default.
- W2013457041 hasRelatedWork W143390371 @default.
- W2013457041 hasRelatedWork W1564850196 @default.
- W2013457041 hasRelatedWork W1967517517 @default.
- W2013457041 hasRelatedWork W1992574923 @default.
- W2013457041 hasRelatedWork W2046037840 @default.
- W2013457041 hasRelatedWork W2102209677 @default.
- W2013457041 hasRelatedWork W2116833792 @default.
- W2013457041 hasRelatedWork W2147766366 @default.
- W2013457041 hasRelatedWork W2408419453 @default.
- W2013457041 hasRelatedWork W2430034614 @default.
- W2013457041 isParatext "false" @default.
- W2013457041 isRetracted "false" @default.
- W2013457041 magId "2013457041" @default.
- W2013457041 workType "article" @default.