Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013459620> ?p ?o ?g. }
- W2013459620 endingPage "9" @default.
- W2013459620 startingPage "1" @default.
- W2013459620 abstract "Purpose. Reliable data about in vivo regulation of cytokines in early ankle osteoarthritis (OA) are still missing. Methods. 49 patients with a mean age of<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mn>33</mml:mn><mml:mo>±</mml:mo><mml:mn>14</mml:mn></mml:math>years undergoing an arthroscopy of the ankle with different stages of chronic OA were prospectively included in a clinical trial. Lavage fluids were analyzed by ELISA. Additionally, clinical parameters and scores (FFI, CFSS, and AOFAS) were evaluated and supplemented by the Kellgren Lawrence Score (KLS) and the ankle osteoarthritis scoring system (AOSS). Results. ICRS grading of cartilage damage, previous operations, and duration of complains were strong indicators for OA progress and showed correlations to age, clinical scores, validated KLS, and AOSS (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.04</mml:mn></mml:math>). Systemic and intraarticular inflammatory parameters were low in all patients. Biochemically, aggrecan and BMP-7 positively indicated OA with statistically significant associations with duration of symptoms, FFI, AOFAS, and KLS (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.04</mml:mn></mml:math>). In contrast, BMP-2 levels showed statistically significant negative correlations to aggrecan or BMP-7 concentrations, which is in line with the negative association with ICRS score and KLS and the positive correlation with FFI (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.03</mml:mn></mml:math>). Conclusions. We were able to identify different key markers of OA in the ankle as aggrecan, BMP-7, and BMP-2, offering starting points for new ways in diagnostics and interventional strategies." @default.
- W2013459620 created "2016-06-24" @default.
- W2013459620 creator A5014075512 @default.
- W2013459620 creator A5036526404 @default.
- W2013459620 creator A5057591208 @default.
- W2013459620 creator A5074912764 @default.
- W2013459620 creator A5081236962 @default.
- W2013459620 creator A5084636709 @default.
- W2013459620 date "2014-01-01" @default.
- W2013459620 modified "2023-09-27" @default.
- W2013459620 title "Biochemical Characterization of Early Osteoarthritis in the Ankle" @default.
- W2013459620 cites W1875943079 @default.
- W2013459620 cites W1963647703 @default.
- W2013459620 cites W1963698651 @default.
- W2013459620 cites W1965306788 @default.
- W2013459620 cites W1965441048 @default.
- W2013459620 cites W1967057044 @default.
- W2013459620 cites W1972602679 @default.
- W2013459620 cites W1974072756 @default.
- W2013459620 cites W1978021545 @default.
- W2013459620 cites W1982224657 @default.
- W2013459620 cites W1984956442 @default.
- W2013459620 cites W1985606434 @default.
- W2013459620 cites W1993980747 @default.
- W2013459620 cites W2010294534 @default.
- W2013459620 cites W2011092653 @default.
- W2013459620 cites W2023318478 @default.
- W2013459620 cites W2039829008 @default.
- W2013459620 cites W2042623727 @default.
- W2013459620 cites W2045392251 @default.
- W2013459620 cites W2070267630 @default.
- W2013459620 cites W2081771171 @default.
- W2013459620 cites W2088773289 @default.
- W2013459620 cites W2090842430 @default.
- W2013459620 cites W2092284288 @default.
- W2013459620 cites W2103145683 @default.
- W2013459620 cites W2105350898 @default.
- W2013459620 cites W2108683297 @default.
- W2013459620 cites W2115702786 @default.
- W2013459620 cites W2116082376 @default.
- W2013459620 cites W2127334272 @default.
- W2013459620 cites W2133059769 @default.
- W2013459620 cites W2135824491 @default.
- W2013459620 cites W2140696977 @default.
- W2013459620 cites W2140819020 @default.
- W2013459620 cites W2147579625 @default.
- W2013459620 cites W2154305744 @default.
- W2013459620 cites W2163719186 @default.
- W2013459620 cites W2247140742 @default.
- W2013459620 cites W2403463974 @default.
- W2013459620 cites W361465518 @default.
- W2013459620 doi "https://doi.org/10.1155/2014/434802" @default.
- W2013459620 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3947760" @default.
- W2013459620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24696644" @default.
- W2013459620 hasPublicationYear "2014" @default.
- W2013459620 type Work @default.
- W2013459620 sameAs 2013459620 @default.
- W2013459620 citedByCount "17" @default.
- W2013459620 countsByYear W20134596202015 @default.
- W2013459620 countsByYear W20134596202016 @default.
- W2013459620 countsByYear W20134596202017 @default.
- W2013459620 countsByYear W20134596202019 @default.
- W2013459620 countsByYear W20134596202020 @default.
- W2013459620 countsByYear W20134596202021 @default.
- W2013459620 countsByYear W20134596202022 @default.
- W2013459620 crossrefType "journal-article" @default.
- W2013459620 hasAuthorship W2013459620A5014075512 @default.
- W2013459620 hasAuthorship W2013459620A5036526404 @default.
- W2013459620 hasAuthorship W2013459620A5057591208 @default.
- W2013459620 hasAuthorship W2013459620A5074912764 @default.
- W2013459620 hasAuthorship W2013459620A5081236962 @default.
- W2013459620 hasAuthorship W2013459620A5084636709 @default.
- W2013459620 hasBestOaLocation W20134596201 @default.
- W2013459620 hasConcept C11413529 @default.
- W2013459620 hasConcept C126322002 @default.
- W2013459620 hasConcept C141071460 @default.
- W2013459620 hasConcept C142724271 @default.
- W2013459620 hasConcept C204787440 @default.
- W2013459620 hasConcept C2776164576 @default.
- W2013459620 hasConcept C2778640784 @default.
- W2013459620 hasConcept C41008148 @default.
- W2013459620 hasConcept C71924100 @default.
- W2013459620 hasConceptScore W2013459620C11413529 @default.
- W2013459620 hasConceptScore W2013459620C126322002 @default.
- W2013459620 hasConceptScore W2013459620C141071460 @default.
- W2013459620 hasConceptScore W2013459620C142724271 @default.
- W2013459620 hasConceptScore W2013459620C204787440 @default.
- W2013459620 hasConceptScore W2013459620C2776164576 @default.
- W2013459620 hasConceptScore W2013459620C2778640784 @default.
- W2013459620 hasConceptScore W2013459620C41008148 @default.
- W2013459620 hasConceptScore W2013459620C71924100 @default.
- W2013459620 hasLocation W20134596201 @default.
- W2013459620 hasLocation W20134596202 @default.
- W2013459620 hasLocation W20134596203 @default.
- W2013459620 hasLocation W20134596204 @default.
- W2013459620 hasLocation W20134596205 @default.
- W2013459620 hasOpenAccess W2013459620 @default.
- W2013459620 hasPrimaryLocation W20134596201 @default.