FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013460488> ?p ?o ?g. }

• W2013460488 endingPage "138" @default.
• W2013460488 startingPage "124" @default.
• W2013460488 abstract "Cytoskeletal protein 4.1R is instrumental in regulating erythrocyte plasticity. 4.1R is comprised of four domains identified after chymotryptic digestion: an N-terminal 30 kDa domain responsible for interaction with membrane proteins, a unique domain, a spectrin-actin binding (SAB) domain, and a C-terminal domain (CTD). 4.1R 30 kDa domain interactions with transmembrane proteins are regulated by the Ca2+/calmodulin (CaM) complex. Unlike mature mammalian erythrocytes, fish erythrocytes remain nucleated. Comparing their cytoskeleton architecture and functional properties is therefore of great interest. Here we characterized the recently cloned zebrafish (Danio rerio, ZF) 4.1R and compared its properties with human 4.1R. We identified three ZF4.1R mRNA transcripts in erythrocytes, all characterized by exclusion of the central domains. The major transcript, referred to as BL31, included a full length 30 kDa domain (ZFR30) and parts of the unique region Ua and of CTD. Two minor transcripts, referred to as BL42 and BL56, expressed parts of ZFR30 and of the unique region Ub and full length SAB and CTD domains. Antibodies to ZFR30, ZF4.1R CTD and ZF glycophorin C (GPC) labeled the ZF erythrocyte plasma membrane. ZFR30 bound to CaM in presence or absence of Ca2+. Resonant mirror detection binding assays revealed that ZFR30 bound to human Band3 with low K(D) (∼ 10nM), and to GPC with higher K(D) (∼ 1nM). The Ca2+/CaM complex did not affect ZFR30 binding to Band3 and GPC. Finally, we confirmed ZFR30 binding to erythrocyte plasma membrane proteins by pulling down ZFR30 with human erythrocyte inside–out vesicles (IOV). This study defines unique structural and functional properties for ZF4.1R." @default.
• W2013460488 created "2016-06-24" @default.
• W2013460488 creator A5002377181 @default.
• W2013460488 creator A5035170452 @default.
• W2013460488 creator A5072805788 @default.
• W2013460488 creator A5076387475 @default.
• W2013460488 date "2007-10-01" @default.
• W2013460488 modified "2023-10-18" @default.
• W2013460488 title "Characterization of protein 4.1R in erythrocytes of zebrafish (Danio rerio): Unique binding properties with transmembrane proteins and calmodulin" @default.
• W2013460488 cites W113497410 @default.
• W2013460488 cites W1501647424 @default.
• W2013460488 cites W1507004420 @default.
• W2013460488 cites W1518808549 @default.
• W2013460488 cites W1559532543 @default.
• W2013460488 cites W1876954435 @default.
• W2013460488 cites W1965227162 @default.
• W2013460488 cites W1979772798 @default.
• W2013460488 cites W2004778528 @default.
• W2013460488 cites W2010237285 @default.
• W2013460488 cites W2013257106 @default.
• W2013460488 cites W2021816748 @default.
• W2013460488 cites W2028094132 @default.
• W2013460488 cites W2037988884 @default.
• W2013460488 cites W2056477864 @default.
• W2013460488 cites W2069455944 @default.
• W2013460488 cites W2070499934 @default.
• W2013460488 cites W2070818399 @default.
• W2013460488 cites W2074137531 @default.
• W2013460488 cites W2085764053 @default.
• W2013460488 cites W2088034755 @default.
• W2013460488 cites W2114451767 @default.
• W2013460488 cites W2114662349 @default.
• W2013460488 cites W2133787519 @default.
• W2013460488 cites W2140064465 @default.
• W2013460488 cites W2323516394 @default.
• W2013460488 cites W2403019844 @default.
• W2013460488 cites W255640021 @default.
• W2013460488 cites W4253038916 @default.
• W2013460488 doi "https://doi.org/10.1016/j.cbpb.2007.05.001" @default.
• W2013460488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17569566" @default.
• W2013460488 hasPublicationYear "2007" @default.
• W2013460488 type Work @default.
• W2013460488 sameAs 2013460488 @default.
• W2013460488 citedByCount "13" @default.
• W2013460488 countsByYear W20134604882012 @default.
• W2013460488 countsByYear W20134604882013 @default.
• W2013460488 countsByYear W20134604882014 @default.
• W2013460488 countsByYear W20134604882015 @default.
• W2013460488 countsByYear W20134604882016 @default.
• W2013460488 crossrefType "journal-article" @default.
• W2013460488 hasAuthorship W2013460488A5002377181 @default.
• W2013460488 hasAuthorship W2013460488A5035170452 @default.
• W2013460488 hasAuthorship W2013460488A5072805788 @default.
• W2013460488 hasAuthorship W2013460488A5076387475 @default.
• W2013460488 hasConcept C104317684 @default.
• W2013460488 hasConcept C111368507 @default.
• W2013460488 hasConcept C118892022 @default.
• W2013460488 hasConcept C125533998 @default.
• W2013460488 hasConcept C125705527 @default.
• W2013460488 hasConcept C127313418 @default.
• W2013460488 hasConcept C142669718 @default.
• W2013460488 hasConcept C1491633281 @default.
• W2013460488 hasConcept C153911025 @default.
• W2013460488 hasConcept C170493617 @default.
• W2013460488 hasConcept C181199279 @default.
• W2013460488 hasConcept C24530287 @default.
• W2013460488 hasConcept C2775847163 @default.
• W2013460488 hasConcept C2776878037 @default.
• W2013460488 hasConcept C2780384893 @default.
• W2013460488 hasConcept C29688787 @default.
• W2013460488 hasConcept C41625074 @default.
• W2013460488 hasConcept C42086223 @default.
• W2013460488 hasConcept C50244902 @default.
• W2013460488 hasConcept C55493867 @default.
• W2013460488 hasConcept C67982717 @default.
• W2013460488 hasConcept C86803240 @default.
• W2013460488 hasConcept C95444343 @default.
• W2013460488 hasConceptScore W2013460488C104317684 @default.
• W2013460488 hasConceptScore W2013460488C111368507 @default.
• W2013460488 hasConceptScore W2013460488C118892022 @default.
• W2013460488 hasConceptScore W2013460488C125533998 @default.
• W2013460488 hasConceptScore W2013460488C125705527 @default.
• W2013460488 hasConceptScore W2013460488C127313418 @default.
• W2013460488 hasConceptScore W2013460488C142669718 @default.
• W2013460488 hasConceptScore W2013460488C1491633281 @default.
• W2013460488 hasConceptScore W2013460488C153911025 @default.
• W2013460488 hasConceptScore W2013460488C170493617 @default.
• W2013460488 hasConceptScore W2013460488C181199279 @default.
• W2013460488 hasConceptScore W2013460488C24530287 @default.
• W2013460488 hasConceptScore W2013460488C2775847163 @default.
• W2013460488 hasConceptScore W2013460488C2776878037 @default.
• W2013460488 hasConceptScore W2013460488C2780384893 @default.
• W2013460488 hasConceptScore W2013460488C29688787 @default.
• W2013460488 hasConceptScore W2013460488C41625074 @default.
• W2013460488 hasConceptScore W2013460488C42086223 @default.
• W2013460488 hasConceptScore W2013460488C50244902 @default.
• W2013460488 hasConceptScore W2013460488C55493867 @default.
• W2013460488 hasConceptScore W2013460488C67982717 @default.

• next