FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013467315> ?p ?o ?g. }

• W2013467315 endingPage "627" @default.
• W2013467315 startingPage "623" @default.
• W2013467315 abstract "To investigate the effects of naloxone and morphine during acute hypoxia.Prospective, randomized animal study.University laboratory.Twenty-eight adult male Sprague Dawley rats, weighing 300-350 g.The rats were implanted with a femoral catheter and subcutaneous electrodes for electrocardiogram recording and were randomly assigned to receive morphine (5 mg/kg), naloxone (5 mg and 10 mg/kg), or normal saline (control) (n = 7 in each). Fifteen minutes after intraperitoneal injection of the drug, each rat was exposed to hypoxic gas (5% oxygen, 95% N2) for 70 mins. Hypoxic survival time was measured. Mean arterial pressure (MAP), arterial pH, Paco2, Pao2, and base excess were measured before injection (baseline), 14 mins after injection (H0), and 6 mins (H1), 33 mins (H2), and 48 mins (H3) after exposure to hypoxia.Hypoxic survival was similar between the naloxone 5 mg/kg and control groups (p = .183), significantly lower in the naloxone 10 mg/kg group (p < .01), and significantly higher in the morphine 5 mg/kg group (p < .05) compared with controls. MAP significantly decreased in all groups. However, at H2-H3, MAP was better preserved in both naloxone groups and was lower in the morphine group compared with controls. Paco2 was maintained higher at H0-H3 in the morphine group and lower at H2-H3 in both naloxone groups compared with controls.During acute hypoxia, naloxone preserves arterial blood pressure and attenuates hypoxic ventilatory depression by antagonizing endogenous opiates, but it does not improve hypoxic survival. In contrast, morphine, which enhances the action of endogenous opiates, does improve hypoxic survival. The acute hypoxic tolerance of morphine may be partly attributable to a depression of oxygen consumption, increased cerebral blood flow secondary to high Paco2, and protective actions mediated by delta-opioid receptors." @default.
• W2013467315 created "2016-06-24" @default.
• W2013467315 creator A5002108612 @default.
• W2013467315 creator A5013828712 @default.
• W2013467315 creator A5031105326 @default.
• W2013467315 creator A5053746933 @default.
• W2013467315 date "2001-03-01" @default.
• W2013467315 modified "2023-10-17" @default.
• W2013467315 title "Naloxone improves arterial blood pressure and hypoxic ventilatory depression, but not survival, of rats during acute hypoxia" @default.
• W2013467315 cites W1789439462 @default.
• W2013467315 cites W1980075929 @default.
• W2013467315 cites W1984086740 @default.
• W2013467315 cites W1987891804 @default.
• W2013467315 cites W2003166698 @default.
• W2013467315 cites W2025851980 @default.
• W2013467315 cites W2036940525 @default.
• W2013467315 cites W2047449662 @default.
• W2013467315 cites W2057782867 @default.
• W2013467315 cites W2057824614 @default.
• W2013467315 cites W2072492290 @default.
• W2013467315 cites W2081648241 @default.
• W2013467315 cites W2087445441 @default.
• W2013467315 cites W2089710352 @default.
• W2013467315 cites W2091600807 @default.
• W2013467315 cites W2094037774 @default.
• W2013467315 cites W2134896123 @default.
• W2013467315 cites W2135692387 @default.
• W2013467315 cites W2151986660 @default.
• W2013467315 cites W2188892353 @default.
• W2013467315 cites W2436560534 @default.
• W2013467315 cites W4250184701 @default.
• W2013467315 doi "https://doi.org/10.1097/00003246-200103000-00027" @default.
• W2013467315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11373431" @default.
• W2013467315 hasPublicationYear "2001" @default.
• W2013467315 type Work @default.
• W2013467315 sameAs 2013467315 @default.
• W2013467315 citedByCount "15" @default.
• W2013467315 countsByYear W20134673152013 @default.
• W2013467315 countsByYear W20134673152015 @default.
• W2013467315 countsByYear W20134673152019 @default.
• W2013467315 countsByYear W20134673152021 @default.
• W2013467315 crossrefType "journal-article" @default.
• W2013467315 hasAuthorship W2013467315A5002108612 @default.
• W2013467315 hasAuthorship W2013467315A5013828712 @default.
• W2013467315 hasAuthorship W2013467315A5031105326 @default.
• W2013467315 hasAuthorship W2013467315A5053746933 @default.
• W2013467315 hasConcept C126322002 @default.
• W2013467315 hasConcept C170493617 @default.
• W2013467315 hasConcept C178790620 @default.
• W2013467315 hasConcept C185592680 @default.
• W2013467315 hasConcept C2776452961 @default.
• W2013467315 hasConcept C2777389121 @default.
• W2013467315 hasConcept C2777397205 @default.
• W2013467315 hasConcept C2777953023 @default.
• W2013467315 hasConcept C2778750930 @default.
• W2013467315 hasConcept C2779537118 @default.
• W2013467315 hasConcept C2781063702 @default.
• W2013467315 hasConcept C3019590667 @default.
• W2013467315 hasConcept C42219234 @default.
• W2013467315 hasConcept C540031477 @default.
• W2013467315 hasConcept C71924100 @default.
• W2013467315 hasConcept C7836513 @default.
• W2013467315 hasConcept C84393581 @default.
• W2013467315 hasConceptScore W2013467315C126322002 @default.
• W2013467315 hasConceptScore W2013467315C170493617 @default.
• W2013467315 hasConceptScore W2013467315C178790620 @default.
• W2013467315 hasConceptScore W2013467315C185592680 @default.
• W2013467315 hasConceptScore W2013467315C2776452961 @default.
• W2013467315 hasConceptScore W2013467315C2777389121 @default.
• W2013467315 hasConceptScore W2013467315C2777397205 @default.
• W2013467315 hasConceptScore W2013467315C2777953023 @default.
• W2013467315 hasConceptScore W2013467315C2778750930 @default.
• W2013467315 hasConceptScore W2013467315C2779537118 @default.
• W2013467315 hasConceptScore W2013467315C2781063702 @default.
• W2013467315 hasConceptScore W2013467315C3019590667 @default.
• W2013467315 hasConceptScore W2013467315C42219234 @default.
• W2013467315 hasConceptScore W2013467315C540031477 @default.
• W2013467315 hasConceptScore W2013467315C71924100 @default.
• W2013467315 hasConceptScore W2013467315C7836513 @default.
• W2013467315 hasConceptScore W2013467315C84393581 @default.
• W2013467315 hasIssue "3" @default.
• W2013467315 hasLocation W20134673151 @default.
• W2013467315 hasLocation W20134673152 @default.
• W2013467315 hasOpenAccess W2013467315 @default.
• W2013467315 hasPrimaryLocation W20134673151 @default.
• W2013467315 hasRelatedWork W1965553576 @default.
• W2013467315 hasRelatedWork W1976096263 @default.
• W2013467315 hasRelatedWork W1994125665 @default.
• W2013467315 hasRelatedWork W2038188337 @default.
• W2013467315 hasRelatedWork W2058407245 @default.
• W2013467315 hasRelatedWork W2066719328 @default.
• W2013467315 hasRelatedWork W2088806437 @default.
• W2013467315 hasRelatedWork W2799396870 @default.
• W2013467315 hasRelatedWork W3048049052 @default.
• W2013467315 hasRelatedWork W68200504 @default.
• W2013467315 hasVolume "29" @default.
• W2013467315 isParatext "false" @default.
• W2013467315 isRetracted "false" @default.

• next