FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013467337> ?p ?o ?g. }

• W2013467337 endingPage "721" @default.
• W2013467337 startingPage "721" @default.
• W2013467337 abstract "Due to the increase in resistance of Plasmodium spp. against available antimalarials, there is a need for new, effective and innovative drugs. The non-mevalonate pathway for the biosynthesis of the universal isoprenoid precursors, which is absent in humans, is suggested as an attractive source of targets for such drugs with a novel mode of action. The biological importance of this pathway to Plasmodium spp. is proven by the efficacy of the clinical candidate fosmidomycin, which inhibits the biosynthesis of isoprenoid precursors; it is, however, less clear which isoprenoid end products are essential for parasite survival. In this Highlight, we identify protein prenylation, isoprene-containing quinone production, N-linked glycosylation as well as carotenoid and vitamin-E biosynthesis as probably essential isoprenoid-dependent physiological processes in Plasmodium. Inhibition of any of these processes blocks parasite development. Furthermore, both protein prenylation of SNARE proteins and a protein tyrosine phosphatase as well as tRNA prenylation have been identified as isoprene-dependent processes for which the physiological role in Plasmodium remains unclear. Therefore, the biosynthetic route to the isoprenoid precursors presents attractive drug targets for the development of antimalarials with novel modes of action." @default.
• W2013467337 created "2016-06-24" @default.
• W2013467337 creator A5082528019 @default.
• W2013467337 creator A5088248857 @default.
• W2013467337 date "2012-01-01" @default.
• W2013467337 modified "2023-09-27" @default.
• W2013467337 title "The isoprenoid-precursor dependence of Plasmodium spp." @default.
• W2013467337 cites W1512031035 @default.
• W2013467337 cites W1533581968 @default.
• W2013467337 cites W1612028526 @default.
• W2013467337 cites W1912527875 @default.
• W2013467337 cites W1966795269 @default.
• W2013467337 cites W1972430667 @default.
• W2013467337 cites W1976977157 @default.
• W2013467337 cites W1984558321 @default.
• W2013467337 cites W1993418815 @default.
• W2013467337 cites W1994675489 @default.
• W2013467337 cites W1994835881 @default.
• W2013467337 cites W2002204776 @default.
• W2013467337 cites W2006155895 @default.
• W2013467337 cites W2010778834 @default.
• W2013467337 cites W2014144838 @default.
• W2013467337 cites W2014668771 @default.
• W2013467337 cites W2023413594 @default.
• W2013467337 cites W2024197752 @default.
• W2013467337 cites W2028520859 @default.
• W2013467337 cites W2031257231 @default.
• W2013467337 cites W2036405416 @default.
• W2013467337 cites W2041952805 @default.
• W2013467337 cites W2042990620 @default.
• W2013467337 cites W2048428839 @default.
• W2013467337 cites W2051044604 @default.
• W2013467337 cites W2062950725 @default.
• W2013467337 cites W2064185406 @default.
• W2013467337 cites W2065011383 @default.
• W2013467337 cites W2067388902 @default.
• W2013467337 cites W2071124826 @default.
• W2013467337 cites W2077648184 @default.
• W2013467337 cites W2077772934 @default.
• W2013467337 cites W2077878953 @default.
• W2013467337 cites W2080392647 @default.
• W2013467337 cites W2083280521 @default.
• W2013467337 cites W2083538904 @default.
• W2013467337 cites W2099440857 @default.
• W2013467337 cites W2110343132 @default.
• W2013467337 cites W2112083317 @default.
• W2013467337 cites W2115360771 @default.
• W2013467337 cites W2116864669 @default.
• W2013467337 cites W2129539565 @default.
• W2013467337 cites W2136040902 @default.
• W2013467337 cites W2138904900 @default.
• W2013467337 cites W2141524476 @default.
• W2013467337 cites W2144944458 @default.
• W2013467337 cites W2147463398 @default.
• W2013467337 cites W2164267446 @default.
• W2013467337 cites W2167074271 @default.
• W2013467337 cites W2168950392 @default.
• W2013467337 cites W2169100396 @default.
• W2013467337 cites W2503657251 @default.
• W2013467337 cites W4231988339 @default.
• W2013467337 cites W4241242732 @default.
• W2013467337 cites W4250995486 @default.
• W2013467337 doi "https://doi.org/10.1039/c2np20013a" @default.
• W2013467337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22555616" @default.
• W2013467337 hasPublicationYear "2012" @default.
• W2013467337 type Work @default.
• W2013467337 sameAs 2013467337 @default.
• W2013467337 citedByCount "21" @default.
• W2013467337 countsByYear W20134673372013 @default.
• W2013467337 countsByYear W20134673372014 @default.
• W2013467337 countsByYear W20134673372015 @default.
• W2013467337 countsByYear W20134673372016 @default.
• W2013467337 countsByYear W20134673372017 @default.
• W2013467337 countsByYear W20134673372018 @default.
• W2013467337 countsByYear W20134673372021 @default.
• W2013467337 countsByYear W20134673372022 @default.
• W2013467337 crossrefType "journal-article" @default.
• W2013467337 hasAuthorship W2013467337A5082528019 @default.
• W2013467337 hasAuthorship W2013467337A5088248857 @default.
• W2013467337 hasConcept C181199279 @default.
• W2013467337 hasConcept C203014093 @default.
• W2013467337 hasConcept C206103511 @default.
• W2013467337 hasConcept C2777313579 @default.
• W2013467337 hasConcept C2778048844 @default.
• W2013467337 hasConcept C2778371730 @default.
• W2013467337 hasConcept C553450214 @default.
• W2013467337 hasConcept C55493867 @default.
• W2013467337 hasConcept C57790582 @default.
• W2013467337 hasConcept C86803240 @default.
• W2013467337 hasConceptScore W2013467337C181199279 @default.
• W2013467337 hasConceptScore W2013467337C203014093 @default.
• W2013467337 hasConceptScore W2013467337C206103511 @default.
• W2013467337 hasConceptScore W2013467337C2777313579 @default.
• W2013467337 hasConceptScore W2013467337C2778048844 @default.
• W2013467337 hasConceptScore W2013467337C2778371730 @default.
• W2013467337 hasConceptScore W2013467337C553450214 @default.
• W2013467337 hasConceptScore W2013467337C55493867 @default.
• W2013467337 hasConceptScore W2013467337C57790582 @default.

• next