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• W2013468151 abstract "Folded conformations of proteins in thermodynamically stable states have long lifetimes. Before it folds into a stable conformation, or after unfolding from a stable conformation, the protein will generally stray from one random conformation to another leading thus to rapid fluctuations. Brief structural changes therefore occur before folding and unfolding events. These short-lived movements are easily overlooked in studies of folding/unfolding for they represent momentary excursions of the protein to explore conformations in the neighborhood of the stable conformation. The present study looks for precursory signatures of protein folding/unfolding within these rapid fluctuations through a combination of three techniques: (1) ultrafast shape recognition, (2) time series segmentation, and (3) time series correlation analysis. The first procedure measures the differences between statistical distance distributions of atoms in different conformations by calculating shape similarity indices from molecular dynamics simulation trajectories. The second procedure is used to discover the times at which the protein makes transitions from one conformation to another. Finally, we employ the third technique to exploit spatial fingerprints of the stable conformations; this procedure is to map out the sequences of changes preceding the actual folding and unfolding events, since strongly correlated atoms in different conformations are different due to bond and steric constraints. The aforementioned high-frequency fluctuations are therefore characterized by distinct correlational and structural changes that are associated with rate-limiting precursors that translate into brief segments. Guided by these technical procedures, we choose a model system, a fragment of the protein transthyretin, for identifying in this system not only the precursory signatures of transitions associated with α helix and β hairpin, but also the important role played by weaker correlations in such protein folding dynamics." @default.
• W2013468151 created "2016-06-24" @default.
• W2013468151 creator A5031921221 @default.
• W2013468151 creator A5034486471 @default.
• W2013468151 creator A5077648365 @default.
• W2013468151 date "2014-05-22" @default.
• W2013468151 modified "2023-10-16" @default.
• W2013468151 title "Precursory signatures of protein folding/unfolding: From time series correlation analysis to atomistic mechanisms" @default.
• W2013468151 cites W1570495375 @default.
• W2013468151 cites W1821638548 @default.
• W2013468151 cites W1823713625 @default.
• W2013468151 cites W1964103559 @default.
• W2013468151 cites W1964533214 @default.
• W2013468151 cites W1965910641 @default.
• W2013468151 cites W1966001866 @default.
• W2013468151 cites W1969130197 @default.
• W2013468151 cites W1969370763 @default.
• W2013468151 cites W1969554454 @default.
• W2013468151 cites W1969615692 @default.
• W2013468151 cites W1970435618 @default.
• W2013468151 cites W1970442252 @default.
• W2013468151 cites W1971747108 @default.
• W2013468151 cites W1973235682 @default.
• W2013468151 cites W1973589187 @default.
• W2013468151 cites W1976560647 @default.
• W2013468151 cites W1978498560 @default.
• W2013468151 cites W1985570405 @default.
• W2013468151 cites W1988713613 @default.
• W2013468151 cites W1991794210 @default.
• W2013468151 cites W1994583626 @default.
• W2013468151 cites W1995283995 @default.
• W2013468151 cites W1997891544 @default.
• W2013468151 cites W1999138897 @default.
• W2013468151 cites W2000408345 @default.
• W2013468151 cites W2001230033 @default.
• W2013468151 cites W2005071879 @default.
• W2013468151 cites W2006914704 @default.
• W2013468151 cites W2008545402 @default.
• W2013468151 cites W2008992182 @default.
• W2013468151 cites W2009929688 @default.
• W2013468151 cites W2014677051 @default.
• W2013468151 cites W2015470526 @default.
• W2013468151 cites W2023548857 @default.
• W2013468151 cites W2023790301 @default.
• W2013468151 cites W2027105865 @default.
• W2013468151 cites W2037324314 @default.
• W2013468151 cites W2038701810 @default.
• W2013468151 cites W2041638382 @default.
• W2013468151 cites W2043580674 @default.
• W2013468151 cites W2050592990 @default.
• W2013468151 cites W2051594610 @default.
• W2013468151 cites W2051821750 @default.
• W2013468151 cites W2057289558 @default.
• W2013468151 cites W2058206198 @default.
• W2013468151 cites W2058469726 @default.
• W2013468151 cites W2061939935 @default.
• W2013468151 cites W2067236515 @default.
• W2013468151 cites W2072603366 @default.
• W2013468151 cites W2075316203 @default.
• W2013468151 cites W2075797983 @default.
• W2013468151 cites W2075894968 @default.
• W2013468151 cites W2076430296 @default.
• W2013468151 cites W2078604215 @default.
• W2013468151 cites W2079884830 @default.
• W2013468151 cites W2081693079 @default.
• W2013468151 cites W2082912027 @default.
• W2013468151 cites W2093221728 @default.
• W2013468151 cites W2093945323 @default.
• W2013468151 cites W2096711507 @default.
• W2013468151 cites W2103032510 @default.
• W2013468151 cites W2106612397 @default.
• W2013468151 cites W2107165577 @default.
• W2013468151 cites W2108102848 @default.
• W2013468151 cites W2111796195 @default.
• W2013468151 cites W2115213105 @default.
• W2013468151 cites W2117513966 @default.
• W2013468151 cites W2117620409 @default.
• W2013468151 cites W2129020329 @default.
• W2013468151 cites W2131985910 @default.
• W2013468151 cites W2134882619 @default.
• W2013468151 cites W2135112949 @default.
• W2013468151 cites W2136989186 @default.
• W2013468151 cites W2146950091 @default.
• W2013468151 cites W2147304700 @default.
• W2013468151 cites W2147396853 @default.
• W2013468151 cites W2155387468 @default.
• W2013468151 cites W2158632698 @default.
• W2013468151 cites W2160721947 @default.
• W2013468151 cites W2160817213 @default.
• W2013468151 cites W2165843192 @default.
• W2013468151 cites W2167564565 @default.
• W2013468151 cites W2168175751 @default.
• W2013468151 cites W2170888068 @default.
• W2013468151 cites W2171755502 @default.
• W2013468151 cites W2313905422 @default.
• W2013468151 cites W2333437802 @default.
• W2013468151 cites W4235474152 @default.
• W2013468151 doi "https://doi.org/10.1063/1.4875802" @default.
• W2013468151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24880323" @default.
• W2013468151 hasPublicationYear "2014" @default.

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