Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013477889> ?p ?o ?g. }
- W2013477889 endingPage "H268" @default.
- W2013477889 startingPage "H259" @default.
- W2013477889 abstract "Dysregulation of autophagy, an evolutionarily conserved process for degradation of long-lived proteins and organelles, has been implicated in the pathogenesis of human disease. Recent research has uncovered pathways that control autophagy in the heart and molecular mechanisms by which alterations in this process affect cardiac structure and function. Although initially thought to be a nonselective degradation process, autophagy, as it has become increasingly clear, can exhibit specificity in the degradation of molecules and organelles, such as mitochondria. Furthermore, it has been shown that autophagy is involved in a wide variety of previously unrecognized cellular functions, such as cell death and metabolism. A growing body of evidence suggests that deviation from appropriate levels of autophagy causes cellular dysfunction and death, which in turn leads to heart disease. Here, we review recent advances in understanding the role of autophagy in heart disease, highlight unsolved issues, and discuss the therapeutic potential of modulating autophagy in heart disease." @default.
- W2013477889 created "2016-06-24" @default.
- W2013477889 creator A5019042345 @default.
- W2013477889 creator A5044383005 @default.
- W2013477889 creator A5046525377 @default.
- W2013477889 creator A5054452204 @default.
- W2013477889 creator A5061402622 @default.
- W2013477889 creator A5091471046 @default.
- W2013477889 date "2015-02-15" @default.
- W2013477889 modified "2023-10-17" @default.
- W2013477889 title "Recent progress in research on molecular mechanisms of autophagy in the heart" @default.
- W2013477889 cites W1523693806 @default.
- W2013477889 cites W1560977824 @default.
- W2013477889 cites W1581683718 @default.
- W2013477889 cites W1928401453 @default.
- W2013477889 cites W1966995952 @default.
- W2013477889 cites W1968322176 @default.
- W2013477889 cites W1973472942 @default.
- W2013477889 cites W1976761774 @default.
- W2013477889 cites W1979462186 @default.
- W2013477889 cites W1979526109 @default.
- W2013477889 cites W1980305749 @default.
- W2013477889 cites W1981206208 @default.
- W2013477889 cites W1982397114 @default.
- W2013477889 cites W1990191024 @default.
- W2013477889 cites W1991387227 @default.
- W2013477889 cites W1996739007 @default.
- W2013477889 cites W1999532278 @default.
- W2013477889 cites W1999801453 @default.
- W2013477889 cites W2001045944 @default.
- W2013477889 cites W2007505836 @default.
- W2013477889 cites W2012040176 @default.
- W2013477889 cites W2013944211 @default.
- W2013477889 cites W2019782533 @default.
- W2013477889 cites W2022964430 @default.
- W2013477889 cites W2024421162 @default.
- W2013477889 cites W2025364264 @default.
- W2013477889 cites W2025665129 @default.
- W2013477889 cites W2026660662 @default.
- W2013477889 cites W2030548258 @default.
- W2013477889 cites W2034087770 @default.
- W2013477889 cites W2036903182 @default.
- W2013477889 cites W2038834667 @default.
- W2013477889 cites W2043276141 @default.
- W2013477889 cites W2048030072 @default.
- W2013477889 cites W2048458549 @default.
- W2013477889 cites W2052101545 @default.
- W2013477889 cites W2052889619 @default.
- W2013477889 cites W2058065156 @default.
- W2013477889 cites W2061473417 @default.
- W2013477889 cites W2062526619 @default.
- W2013477889 cites W2062629975 @default.
- W2013477889 cites W2063761428 @default.
- W2013477889 cites W2064597059 @default.
- W2013477889 cites W2067097574 @default.
- W2013477889 cites W2068231534 @default.
- W2013477889 cites W2072948635 @default.
- W2013477889 cites W2075058886 @default.
- W2013477889 cites W2076544864 @default.
- W2013477889 cites W2078184757 @default.
- W2013477889 cites W2078940387 @default.
- W2013477889 cites W2085367705 @default.
- W2013477889 cites W2086557228 @default.
- W2013477889 cites W2091210052 @default.
- W2013477889 cites W2092943609 @default.
- W2013477889 cites W2094780189 @default.
- W2013477889 cites W2094898345 @default.
- W2013477889 cites W2095000965 @default.
- W2013477889 cites W2099970328 @default.
- W2013477889 cites W2101051879 @default.
- W2013477889 cites W2102238895 @default.
- W2013477889 cites W2106296270 @default.
- W2013477889 cites W2106444069 @default.
- W2013477889 cites W2109034822 @default.
- W2013477889 cites W2109569600 @default.
- W2013477889 cites W2110949768 @default.
- W2013477889 cites W2111009165 @default.
- W2013477889 cites W2111559564 @default.
- W2013477889 cites W2113913169 @default.
- W2013477889 cites W2115742671 @default.
- W2013477889 cites W2119237563 @default.
- W2013477889 cites W2119421712 @default.
- W2013477889 cites W2121520913 @default.
- W2013477889 cites W2126943184 @default.
- W2013477889 cites W2135592618 @default.
- W2013477889 cites W2138886500 @default.
- W2013477889 cites W2139636031 @default.
- W2013477889 cites W2145084709 @default.
- W2013477889 cites W2145206598 @default.
- W2013477889 cites W2147553897 @default.
- W2013477889 cites W2152674951 @default.
- W2013477889 cites W2161594732 @default.
- W2013477889 cites W2164174765 @default.
- W2013477889 cites W2164778558 @default.
- W2013477889 cites W2164945122 @default.
- W2013477889 cites W2165316137 @default.
- W2013477889 cites W2167867141 @default.
- W2013477889 cites W2171317360 @default.