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- W2013479922 abstract "Fasciola hepatica causes biliary epithelial hyperplasia and obstructive jaundice in humans and animals. Using a planar lipid bilayer technique, we further characterized the single channel property of large conductance K + -permeable channels that were previously identified from F. hepatica . The single channel conductance was 254.7 ± 17.9 pS under a symmetrical 200/200 mM ( cis / trans ) KCl gradient. Open state probability ( P o ) varied from channel to channel at a given membrane potential and Ca 2+ concentration, but increased with voltage (−60 to +40 mV) and cis Ca 2+ (1–200 μM). Under a near bi-ionic condition of 200 mM [K + ] cis /200 mM [Na + ] trans , the permeability ratio of K + to Na + was 5.0. Charybdotoxin (1 μM) inhibited P o , whereas tetraethylammonium reduced the conductance ( K D = 67.8 mM). Taken together, the results show that the single channel properties of the large conductance K + -permeable channels in F. hepatica are similar to those of large conductance Ca 2+ -activated K + (BK) channels in general, but distinct from typical BK channels in the extent of voltage- and Ca 2+ -dependence, as well as permeability to Na + . This study further reveals a variant BK channel in F. hepatica that could serve as a new drug target to treat fascioliasis." @default.
- W2013479922 created "2016-06-24" @default.
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- W2013479922 date "2012-05-01" @default.
- W2013479922 modified "2023-09-24" @default.
- W2013479922 title "Property of large conductance Ca2+-activated K+ channels from Fasciola hepatica incorporated into planar lipid bilayer" @default.
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- W2013479922 doi "https://doi.org/10.1016/j.vetpar.2011.11.038" @default.
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